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Synfacts 2008(6): 0554-0554  
DOI: 10.1055/s-2008-1072601
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Dysiherbaine

Contributor(s): Philip Kocienski, Indu Dager
M. Sasaki*, K. Tsubone, K. Aoki, N. Akiyama, M. Shoji, M. Oikawa, R. Sakai, K. Shimamoto
Tohoku University, Sendai, Kitasato University, Iwate and Suntory Institute of Bioorganic Research, Osaka, Japan
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Publication History

Publication Date:
21 May 2008 (online)

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Significance

Dysiherbaine is an excitatory amino acid with potent convulsant activity that is isolated from the sponge Dysidea herbacea. It shows a strong affinity for KA classes of receptors and activates AMPA classes of receptors as well. Dysiherbaine is also capable of inducing long-lasting epileptic-like seizures in mice.