Benzodiazepine Withdrawal Syndrome Seizures

H. Martínez-Cano; A. Vela-Bueno; M. de Iceta; R. Pomalima; I. Martínez-Gras

doi:10.1055/s-2007-979613

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Pharmacopsychiatry 1995; 28(6): 257-262
DOI: 10.1055/s-2007-979613

Original Paper

Benzodiazepine Withdrawal Syndrome Seizures

H. Martínez-Cano¹ ^, ² , A. Vela-Bueno¹ ^, ⁴ , M. de Iceta³ , R. Pomalima⁴ ^, ⁵ , I. Martínez-Gras²

¹Department of Psychiatry, Autonomous University of Madrid, Spain
²Department of Psychiatry, Princess Hospital, Madrid, Spain
³Department of Psychiatry, San Carlos University Hospital, Madrid, Spain
⁴Sleep Disorders Centre, Madrid, Spain
⁵NIMH H. Delgado-H. Noguchi, Lima, Peru

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Publication History

Publication Date:
23 April 2007 (online)

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Abstract

In this study, we present five cases of seizures following withdrawal of flunitrazepam, lorazepam, or triazolam, representing 3 % of a sample consisting of 153 patients dependent on benzodiazepines. Both abrupt cessation of benzodiazepine intake and high-dose use seem to be critical for the appearance of seizures. Pharmacological features, such as short elimination half-life and high potency, might explain the higher risk of seizures observed in these patients.

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