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Horm Metab Res 1987; 19(8): 371-374
DOI: 10.1055/s-2007-1011827
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Evaluation of Neutrophil Activity and Circulating Immune Complexes Levels in Diabetic Patients

Rosa Inés Barañao, J. C. Garberi, P. A. Tesone, Lía S. Rumi
  • Instituto de Biología y Medicina Experimental, Buenos Aires, Argentina
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Publication History

1986

1986

Publication Date:
14 March 2008 (online)

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Summary

We have studied chemiluminescence produced by neutrophils stimulated by opsonized zymosan in insulin dependent (IDD) and non insulin dependent (NIDD) diabetic patients. Chemiluminescence was evaluated as the integral and maximum peak, total time and time to maximum peak of the response curve to opsonized zymosan. These values were then compared with circulating immune complexes (CIC) and glucose levels. Both IDD and NIDD patients had significantly higher values of chemiluminescence and CIC than normal controls. We also observed that patients who had the highest values of CIC and chemiluminescence levels were the ones with clinical microvascular complications.

Key-Words

Neutrophils - Chemiluminescence - Diabetes - Circulating Immune Complexes - Oxidative Metabolism

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