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Planta Med 1992; 58(5): 436-441
DOI: 10.1055/s-2006-961508
Paper

© Georg Thieme Verlag Stuttgart · New York

Evaluation of Plant Extracts for Antileishmanial Activity using a Mechanism-Based Radiorespirometric Microtechnique (RAM)

Maurice M. Iwu1 , 2 , Joan E. Jackson3 , John D. Tally3 , Daniel L. Klayman2
  • 1NRC Senior Research Associate; on leave of absence from the University of Nigeria, Nsukka, Nigeria
  • 2Department of Medicinal Chemistry, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, D.C. 20307, U.S.A.
  • 3Department of Parasitology, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, D.C. 20307, U.S.A.
Further Information

Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

Extracts of eleven plants used in Nigerian traditional medicine have been evaluated for possible antileishmanial activity using a radiorespirometric microtest technique based on in vitro inhibition of catabolism of 14CO2, from a battery of 14C-substrates by promastigotes. Of 13 methanol extracts tested, 5 from Gongronema latifolia, Dorstenia multiradiata, Picralima nitida. Cola attiensis, and Desmodium gangeticnm, were active at concentrations of 50 µg/ml or less against a visceral Leishmaniaisolate.

Key words

Leishmaniasis - Gongronema latifolia - Dorstenia multiradiata - Picralima nitida - Desmodium gangeticum - Cola attiensis

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