Download PDF
Planta Med 2006; 72(14): 1347-1349
DOI: 10.1055/s-2006-951735
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Potent Antitumor Activity of 3,4-seco-8βH-Ferna-4(23),9(11)-dien-3-oic Acid (EC-2) and 3,4-seco-Oleana-4(23),18-dien-3-oic Acid (EC-4), Evaluated by an in vitro Human Cancer Cell Line Panel

Reiko Tanaka1 , Shun-ichi Wada1 , Takeshi Yamada1 , Takao Yamori2
  • 1Department of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
  • 2Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan
Further Information

Publication History

Received: May 8, 2006

Accepted: August 25, 2006

Publication Date:
18 October 2006 (online)

    Permissions and Reprints

Abstract

3,4-seco-8βH-Ferna-4(23),9(11)-dien-3-oic acid (EC-2) (1) and 3,4-seco-oleana-4(23),18-dien-3-oic acid (EC-4) (2) isolated from the whole herb of Euphorbia chamaesyce L. were evaluated for their anti-tumor activities using a panel including 39 human cancer cell lines (HCC) coupled with a drug sensitivity database. Compounds 1 and 2 showed strong cytotoxicity against the HCC panel, even though alcohols 1a and 2a and methyl esters 1b and 2b were inactive.

References

  • 1 Tanaka R, Ida T, Kita S, Kamisako W, Matsunaga S. 3,4-seco-Oleana-8βH-fernadienoic acid and other constituents from Euphorbia chamaesyce .  Phytochemistry. 1996;  41 1163-8
    CrossrefPubMedGoogle Scholar
  • 2 Tanaka R, Ida T, Takaoka Y, Kita S, Kamisako W, Matsunaga S. 3,4-seco-Oleana-4(23),18-dien-3-oic acid and other triterpenes from Euphorbia chamaesyce .  Phytochemistry. 1994;  36 129-32
    CrossrefPubMedGoogle Scholar
  • 3 Wada S, Tanaka R, Iida A, Matsunaga S. In vitro inhibitory effects of DNA topoisomerase II by fernane-type triterpenoids isolated from a Euphorbia genes.  Bioorg Med Chem Lett. 1998;  28 1219-23
    PubMedGoogle Scholar
  • 4 Karim R, Iwai S, Morimura K, Wanibuchi H, Tanaka R, Matsunaga S. et al . Lack of modification of rat hepatocarcinogenesis by fernane-type triterpenoids, isolated from a Euphorbia genus.  Teratog Carcinog Mutagen. 2002;  22 293-9
    CrossrefPubMedGoogle Scholar
  • 5 Yamori T, Matsunaga A, Sato S, Yamazaki K, Komi A, Ishizu K. et al . Potent antitumor activity of MS-247, a novel DNA minor groove binder, evaluated by an in vitro and in vivo human cancer cell line panel.  Cancer Res. 1999;  59 4042-9
    PubMedGoogle Scholar
  • 6 Paull K D, Shomaker R H, Hodes L, Monks A, Scudiero D A, Rubinstein L. et al . Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithum.  J Natl Cancer Inst. 1989;  81 1088-92
    CrossrefPubMedGoogle Scholar
  • 7 Takada Y, Aggarwal B B. Betulinic acid suppresses carcinogen-induced NF-κB activation through inhibition of IκBa kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.  J Immunol. 2003;  171 3278-86
    PubMedGoogle Scholar
  • 8 Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D. et al . Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.  J Natl Cancer Inst. 1991;  83 757-66
    CrossrefPubMedGoogle Scholar
  • 9 Stinson S F, Alley M C, Kopp W C, Fiebig H H, Mullendore L A, Pittman A F. et al . Morphological and immunocytochemical characteristics of human tumor cell lines for use in a disease-oriented anticancer drug screen.  Anticancer Res. 1992;  12 1035-53
    PubMedGoogle Scholar
  • 10 Yaguchi S, Fukui Y, Koshimizu I, Yoshimi H, Matsuno T, Gouda H. et al . Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.  J Natl Cancer Inst. 2006;  98 545-56
    PubMedGoogle Scholar

Dr. Reiko Tanaka

Department of Medicinal Chemistry

Osaka University of Pharmaceutical Sciences

4-20-1 Nasahara

Takatsuki

Osaka 569-1094

Japan

Phone: +81-72-690-1084

Fax: +81-72-690-1084

Email: tanakar@gly.oups.ac.jp

      >