A New Cytotoxic Phenylbutenoid Dimer from the Rhizomes of Zingiber cassumunar

 

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Abstract

A new phenylbutenoid dimer, (±)-trans-3-(4-hydroxy-3-methoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, was isolated from the rhizomes of Zingiber cassumunar along with the three known compounds, (±)-trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, 4-(3,4-dimethoxyphenyl)but-1,3-diene, and 4-(2,4,5-trimethoxyphenyl)but-1,3-diene by bioassay-directed fractionation using the A549 human cancer cell line cytotoxicity assay. Structure of the new compound was elucidated by spectral analysis, including 1D and 2D NMR experiments.

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Prof. Eun-Kyoung Seo, Ph. D.

Natural Products Chemistry Laboratory

College of Pharmacy

Ewha Womans University

Seoul 120-750

Korea

Phone: +82-2-3277-3047

Fax: +82-2-3277-3051

Email: Yuny@ ewha.ac.kr