3-Acylindoles via a One-Pot, Regioselective Friedel-Crafts Reaction

 

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Abstract

Within we report a general one-pot high-yielding Friedel-Crafts acylation of indole using acid chlorides and diethyl­aluminum chloride in gram scale quantities. This general synthesis affords products that are easily isolated and require no complex purification procedures.

References

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Wynne, J. H.; Jones-Meehan, J. US Naval Research Laboratory, Washington, D. C., 2004, unpublished work.