Sentinel-Node-Biopsy: Bedeutung für Prognose und Therapie

 

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Zusammenfassung

Die Wächterlymphknotenbiopsie gewährleistet eine sehr zuverlässige Ausbreitungsdiagnostik des regionären Lymphabflussgebietes für Patienten mit primärem Melanom. Der histologische Status des Wächterlymphknotens ist von herausragender prognostischer Bedeutung. Innerhalb der histologisch positiven Patienten können anhand des Tumordurchmessers prognostische heterogene Gruppen identifiziert werden. Aufgrund der erhöhten Sensitivität zur Tumorzelldetektion kann durch die zusätzliche Durchführung von RT-PCR-Untersuchungen eine Verbesserung der prognostischen Relevanz der Wächterlymphknotenbiopsie erzielt werden.

Abstract

The technique of sentinel lymph node biopsy is highly accurate in staging the regional lymph node basins in primary melanoma patients. The histological status of the sentinel lymph node is one of the most important prognostic factors for recurrence. In patients with positive histological status the extend of nodal tumour mass has been to shown to correlate with recurrence. Due to the increased sensitivity of tumour cell detection by molecular biological techniques the additional use of RT-PCR is able to improve the clinical impact of sentinel lymph node biopsy.

Literatur

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H.-J. Blaheta

Universitäts-Hautklinik Tübingen

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