Further evidence for direct vascular actions of statins: Effect on endothelial nitric oxide synthase and adhesion molecules

 

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Summary:

The effect of the synthetic statin fluvastatin was investigated on the concentrations of endothelial nitric oxide synthase (eNOS) and of soluble adhesion molecules in human vascular endothelial cell cultures. Fluvastatin was able to increase dose-dependently eNOS concentration. In addition, fluvastatin reduced concentrations of E-Selectin and ICAM-1. These results further support the evidence that statins elicit important effects on the vascular endothelium which may contribute to the reduction of morbidity and mortality of cardiovascular diseases.

References

• 1 Bourcier T, Libby P. HMG CoA Reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells.  Arterioscler Thromb Vasc Biol. 20 556-562 2000; 
  PubMedGoogle Scholar
• 2 Hernandez-Perera O, Perez-Sala D, Navarro-Antolin J, Sanchez-Pascuala R, Hernandez G, Diaz C, Lamas S. Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells.  J Clin Invest. 101 2711-2719 1998; 
  PubMedGoogle Scholar
• 3 Kano H, Hayashi T, Sumi D, Esaki T, Asai Y, Thakur N K, Jayachandran M, Iguchi A. A HMG-CoA reductase inhibitor improved regression of atherosclerosis in the rabbit aorta without affecting serum lipid levels: possible relevance of up-regulation of endothelial NO synthase mRNA.  Biochem Biophys Res Commun. 259 414-419 1999; 
  CrossrefPubMedGoogle Scholar
• 4 Mueck A O, Seeger H, Wallwiener D. Fluvastatin combined with 17β-estradiol: Effect on the oxidation of human low density lipoprotein.  Experim Clin Endocrinol Diabetes. 108 316-317 2000; 
  PubMedGoogle Scholar
• 5 Negre-Aminou P, van Vliet A K, van Erck M, van Thiel C F, van Leeuwen R EW, Cohen L H. Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types.  Biochimica Biophysica Acta. 1345 259-268 1997; 
  PubMedGoogle Scholar
• 6 Romano M, Mezzetti A, Marulli C, Ciabattoni G, Febo F, Di-Ienno S, Roccaforte S, Vigneri S, Nubile G, Milani M, Davi G. Fluvastatin reduces soluble P-selectin and ICAM-1 levels in hypercholesterolemic patients: role of nitric oxide.  J Investig Med. 48 183-189 2000; 
  PubMedGoogle Scholar
• 7 Seeger H, Mueck A O, Lippert T H. Fluvastatin increases prostacyclin and decreases endothelin production by human umbilical vein endothelial cells.  Int J Clin Pharm Therap. 38 270-272 2000; 
  PubMedGoogle Scholar

A. O. MueckMD, PhD, PH 

Head of Section of Gynecological Endocrinology and Menopause

Department of Obstetrics and Gynecology

Schleichstr. 4

D-72076 Tuebingen

Germany

Phone: + 49-70 71-29 84 80 1

Fax: + 49-70 71-29 48 01

Email: endo.meno@med.uni-tuebingen.de