A New Diterpenoid with Antispasmodic Activity from Salvia cinnabarina

 

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Abstract

From the leaf surface exudate of the aerial parts of Salvia cinnabarina a new secoisopimarane diterpenoid with a non-specific spasmolytic activity on histamine-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum was obtained. The IC₅₀ value obtained was comparable with that obtained for papaverine. The structure of 3,4-secoisopimara-4(18),7,15-triene-3-oic acid was established by 1D and 2D NMR spectroscopic techniques.

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Prof. G. Romussi

Dipartimento di Chimica e Tecnologie Farmaceutiche ed Alimentari

Università di Genova

Via Brigata Salerno

16147 Genova

Italy

Email: romussi@dictfa.unige.it