Molluscicidal and Trypanocidal Activities of Lapachol Derivatives

 

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Abstract

The activity of the potassium salt of lapachol against the snail Biomphalaria glabrata and its egg masses was tested. The obtained IC₅₀ values (2.70 ppm and 1.43 ppm, respectively) are indicative of a strong activity. Lapachol derivatives were also assayed against infective trypomastigote blood forms of T. cruzi and the triacetoxy derivative of reduced lapachol showed relevant trypanocidal activity, killing 95.7 % of the parasites at the concentration of 42 μg/mL.

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Marília Oliveira Fonseca Goulart

Departamento de Química

Centro de Ciências Exatas e Naturais

Universidade Federal de Alagoas

Tabuleiro do Martins

Maceió, Alagoas, 57072-970

Brasil

Email: mofg@qui.ufal.br;

Phone: 005582-2141389