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Synthesis 1992; 1992(5): 449-451
DOI: 10.1055/s-1992-26131
short paper
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A Novel Approach to the Synthesis of Symmetric Optically Active 2,5-Dioxopiperazines

Vladimir A. Basiuk* , Taras Yu. Gromovoy, Alexei A. Chuiko, Vadim A. Soloshonok, Valery P. Kukhar
  • *Institute of Surface Chemistry, Academy of Sciences, Ukrainian S.S.R., Prospekt Nauki 31, Kiev 252 028, Ukraine
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Publication Date:
17 September 2002 (online)

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"Gas-solid-phase" method for the preparation of some cyclic dipeptides, 2,5-dioxopiperazines (diketopiperazines), is described. The method implies cyclodimerization of vaporous aliphatic α-amino acids in the presence of silica at reduced pressure and yields optically active 2,5-dioxopiperazines.

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