Synthesis 1991; 1991(2): 141-146
DOI: 10.1055/s-1991-26399
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Synthesis and Spectroscopic Properties of Azaglutamine Amino Acid and Peptide Derivatives

C. J. Gray* , M. Quibell, K. -L. Jiang, N. Baggett
  • *School of Chemistry, University of Birmingham, Edgbaston, P.O. Box 363, Birmingham B15 2TT, England
Further Information

Publication History

Publication Date:
27 September 2002 (online)

tert-Butyl carbazate and Boc-amino acid hydrazides undergo a Michael addition with acrylamide to give substituted carbazates having the side-chain of glutamine on nitrogen. These carbazates may react with chloroformates to give protected azaglutamine esters, and N-activated amino acid esters to give azaglutamine peptides.

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