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Synthesis 1990; 1990(3): 253-255
DOI: 10.1055/s-1990-26846
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A New Synthesis of 1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquinolines

Atanas P. Venkov* , Daniel M. Vodenicharov
  • *Department of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria
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Publication Date:
17 September 2002 (online)

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1,2,3,4-Tetrahyro-2-methyl-4-phenylisoquinolines 6 are obtained from aromatic aldehydes 1, methyl amine and α-haloacetophenones 2 in the presence of sodium borohydride followed by cyclization with sulfuric acid and zinc in methanol.

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