Endoscopy 2023; 55(S 02): S165
DOI: 10.1055/s-0043-1765422
Abstracts | ESGE Days 2023
ePoster

Reversible electroporation for palliation of anemia from unresectable gastrointestinal (GI) tumors. A preliminary experience

P. Fusaroli
1   University of Bologna, Via Zamboni, Bologna, Italy
,
G. Gibiino
2   AUSL Romagna – Sede Cesena, Cesena, Italy
,
A. Lisotti
3   University of Bologna – Faculty of Medicine, Imola, Italy
,
C. Binda
4   Ospedale "Morgagni – Pierantoni" di Forlì, Forlì, Italy
,
A. Cominardi
5   Ospedale "Guglielmo da Saliceto", Piacenza, Italy
,
M. Sbrancia
4   Ospedale "Morgagni – Pierantoni" di Forlì, Forlì, Italy
,
S. Guglielmo
6   Gastroenterology Unit, Imola, Italy
,
C. Fabbri
4   Ospedale "Morgagni – Pierantoni" di Forlì, Forlì, Italy
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Aims Assess endoscopic reversible electroporation for palliation of anemia in GI malignancies.

Methods A single-use device (EndoVE, Mirai Medical, Ireland) was used with a dedicated generator (ePORE). The transparent tip of the device allowed for proper endoscopic orientation and needle injection of calcium in the submucosa, which was necessary prior to each current delivery via the electrode on the tumor, lasting approx. 30-40 secs. Deep sedation was used.

Results The main outcome was met in 4 patients with inoperable GI malignancies that caused clinically significant anemia. Patient 1 was an 82 y-old man suffering from a small gastric metastasis (20 mm) from renal cell cancer; after treatment, he could restart treatment with tyrosine-kinase inhibitors and remained free from anemia for 12 months until his death due to disease progression. Patient 2 was a 72 y-old woman affected by an advanced gastric adenocarcinoma (60 mm); after treatment, she was started on chemotherapy and remained symptom-free at 6 months. Patient 3 was an 87 y-old man with rectal cancer (25 mm) and concomitant anticoagulant therapy; the treatment was technically successful, however, the patient expired 25 days later due to cardiovascular causes. Patient 4 was a 69 y-old man with esophageal moderately differentiated adenocarcinoma (25 mm) and status post-pancreaticoduodenectomy for papillary intraductal carcinoma (2003); he remained symptom-free at 3 months. The procedures were judged easy by the operators; the duration was 20-50 minutes. They were well tolerated in all cases and no adverse events occurred.

Conclusions In our case series, reversible endoscopic electroporation was feasible, safe, and effective for the palliation of anemia due to unresectable GI malignancies.



Publication History

Article published online:
14 April 2023

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