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Thromb Haemost 1979; 42(01): 174
DOI: 10.1055/s-0039-1684687
Platelet - Vessel Wall Interaction
Poster board
Schattauer GmbH

Prostacyclin: Production by Vascular Endothelium and Effects on Platelet Aggregation

S. Moncada
1   Dept. of Prostaglandin Research, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS.
,
S. Bunting
1   Dept. of Prostaglandin Research, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS.
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Publication Date:
26 April 2019 (online)

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The inhibitory effect of vascular endothelial cells on platelet aggregation is due to their ability to release prostacyclin. The existence of an ADPase has been confirmed in endothelial cells but this enzymes does not seem to be related to the anti-aggregating properties of vascular endothelium. In vitro, the release of prostacyclin by humand and rabbit endothelial cells persists after several subcultures. The production of PGI2 can be demonstrated by its inhibition by aspirin-like drugs or 15-hydroperoxy arachidonic acid (a specific inhibitor of PGI2 synthesis). Moreover, the antiaggregating activity is antagonised by an antibody to 5,6 dihydro prostacyclin which cross reacts and neutralises prostacyclin.