Pneumologie 2019; 73(02): 119
DOI: 10.1055/s-0039-1678414
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

Pro-Viral miRNAs Detected in BALF Extracellular Vesicles of Patients with Influenza Virus-Induced ARDS

N. Scheller
1   Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany
,
S. Herold
2   Department of Internal Medicine II, Universities of Giessen and Marburg Lung Center, Justus Liebig University, Member of the German Center for Lung Research (DZL), Giessen, Germany
,
R. Kellner
3   Max Planck Institute for Plant Breeding Research, Cologne, Germany
,
W. Bertrams
1   Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany
,
A. L. Jung
1   Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany
,
H. Janga
4   Institute for Lung Research/iLung, Research Group “RNA-Biology of Inflammation & Infection”, Philipps University, Marburg, Germany
,
T. Greulich
5   Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University, Member of the German Center for Lung Research (DZL), Marburg, Germany
,
L. N. Schulte
4   Institute for Lung Research/iLung, Research Group “RNA-Biology of Inflammation & Infection”, Philipps University, Marburg, Germany
,
C. F. Vogelmeier
5   Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University, Member of the German Center for Lung Research (DZL), Marburg, Germany
,
J. Lohmeyer
2   Department of Internal Medicine II, Universities of Giessen and Marburg Lung Center, Justus Liebig University, Member of the German Center for Lung Research (DZL), Giessen, Germany
,
B. Schmeck
1   Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany
5   Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University, Member of the German Center for Lung Research (DZL), Marburg, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
15 February 2019 (online)

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Influenza A virus (IAV) causes severe respiratory infections and alveolar epithelial damage resulting in acute respiratory distress syndrome (ARDS). Extracellular vesicles (EV) have been shown to mediate cellular crosstalk in inflammation by transfer of microRNAs. In this study, we found significant changes in the miRNA composition of EVs in the broncho-alveolar lavage fluid (BALF) from patients with IAV-induced ARDS. Among the nine significantly deregulated microRNAs, miR-17-5p was upregulated in patientsʼ BALF, and in EVs of IAV-infected lung epithelial cells. In these cells, transfer of miR-17-5p strongly downregulated expression of the antiviral factor Mx1 and significantly enhanced IAV replication.