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Thromb Haemost 1959; 03(02): 257-270
DOI: 10.1055/s-0038-1654386
Originalarbeiten — Original Articles — Travaux Originaux
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Urokinase Excretion in Health and its Alteration in Certain Disease States

Fotios E Smyrniotis   *
1   Department of Internal Medicine, Washington U. School of Medicine St. Louis, Mo.
,
Anthony P Fletcher
1   Department of Internal Medicine, Washington U. School of Medicine St. Louis, Mo.
,
Norma Alkjaersig
1   Department of Internal Medicine, Washington U. School of Medicine St. Louis, Mo.
,
Sol Sherry
1   Department of Internal Medicine, Washington U. School of Medicine St. Louis, Mo.
› Author AffiliationsSupported by grants from the National Heart Institute, Public Health Service, Bethesda, Md., and Lederle Laboratories Division, American Cyanamid Co., Pearl River, N. Y.
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Publication Date:
08 June 2018 (online)

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Summary

1. Urokinase excretion rates in normal subjects were found to be independent of age, sex and urine volume.

2. Urokinase excretion rates were found to be raised following the onset of myocardial infarction (p < 0.001) and after an attack of coronary insufficiency (p = 0.02). Excretion rates were depressed in patients suffering from carcinomatosis (p < 0.001), congestive cardiac failure (0.05 < p < 0.1) and uremia (p < 0.001).

3. These differences suggest that significant alterations in the plasma fibrinolytic system may result as a consequence of disease states.

* Present address: Gastric Laboratory, Cincinnati General Hospital, Cincinnati, O.


 

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