Thyroid Dysfunction and Male Reproductive Physiology

 

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Abstract

Normal thyroid physiology is paramount for the proper development and important for the maintenance of male reproduction. Both short- and long-term deviations in thyroid hormone levels have been shown to alter male reproductive function on a micro- and macroscopic level. Thyrotoxicosis and hypothyroidism are associated with changes in spermatogenesis, semen quality, levels of sexual hormones, and erectile function. However, the degree to which thyroid dysfunction is clinically responsible for male infertility has not been clearly elucidated.

• References

• 1 Lawton NF, Ellis SM, Sufi S. The triiodothyronine and thyroxine response to thyrotrophin-releasing hormone in the assessment of the pituitary-thyroid axis. Clin Endocrinol (Oxf) 1973; 2 (1) 57-63
  CrossrefPubMedGoogle Scholar
• 2 Röjdmark S, Berg A, Kallner G. Hypothalamic-pituitary-testicular axis in patients with hyperthyroidism. Horm Res 1988; 29 (5–6) 185-190
  CrossrefPubMedGoogle Scholar
• 3 Honbo KS, van Herle AJ, Kellett KA. Serum prolactin levels in untreated primary hypothyroidism. Am J Med 1978; 64 (5) 782-787
  CrossrefPubMedGoogle Scholar
• 4 Holsberger DR, Cooke PS. Understanding the role of thyroid hormone in Sertoli cell development: a mechanistic hypothesis. Cell Tissue Res 2005; 322 (1) 133-140
  CrossrefPubMedGoogle Scholar
• 5 Hess RA, Cooke PS, Bunick D, Kirby JD. Adult testicular enlargement induced by neonatal hypothyroidism is accompanied by increased Sertoli and germ cell numbers. Endocrinology 1993; 132 (6) 2607-2613
  CrossrefPubMedGoogle Scholar
• 6 Palmero S, de Marchis M, Gallo G, Fugassa E. Thyroid hormone affects the development of Sertoli cell function in the rat. J Endocrinol 1989; 123 (1) 105-111
  CrossrefPubMedGoogle Scholar
• 7 Gilleron J, Nebout M, Scarabelli L , et al. A potential novel mechanism involving connexin 43 gap junction for control of Sertoli cell proliferation by thyroid hormones. J Cell Physiol 2006; 209 (1) 153-161
  CrossrefPubMedGoogle Scholar
• 8 Lui WY, Mruk D, Lee WM, Cheng CY. Sertoli cell tight junction dynamics: their regulation during spermatogenesis. Biol Reprod 2003; 68 (4) 1087-1097
  CrossrefPubMedGoogle Scholar
• 9 Ariyaratne HB, Mills N, Mason JI, Mendis-Handagama SM. Effects of thyroid hormone on Leydig cell regeneration in the adult rat following ethane dimethane sulphonate treatment. Biol Reprod 2000; 63 (4) 1115-1123
  CrossrefPubMedGoogle Scholar
• 10 Hardy MP, Kirby JD, Hess RA, Cooke PS. Leydig cells increase their numbers but decline in steroidogenic function in the adult rat after neonatal hypothyroidism. Endocrinology 1993; 132 (6) 2417-2420
  CrossrefPubMedGoogle Scholar
• 11 Jana NR, Halder S, Bhattacharya S. Thyroid hormone induces a 52 kDa soluble protein in goat testis Leydig cell which stimulates androgen release. Biochim Biophys Acta 1996; 1292 (2) 209-214
  CrossrefPubMedGoogle Scholar
• 12 Biswas NM, Ghosh PK, Biswas R, Ghosh D. Effect of thyroidectomy, and thyroxine and alpha 2u-globulin replacement therapy on testicular steroidogenic and gametogenic activities in rats. J Endocrinol 1994; 140 (3) 343-347
  CrossrefPubMedGoogle Scholar
• 13 Anderson DC. Sex-hormone-binding globulin. Clin Endocrinol (Oxf) 1974; 3 (1) 69-96
  CrossrefPubMedGoogle Scholar
• 14 Ruder H, Corvol P, Mahoudeau JA, Ross GT, Lipsett MB. Effects of induced hyperthyroidism on steroid metabolism in man. J Clin Endocrinol Metab 1971; 33 (3) 382-387
  CrossrefPubMedGoogle Scholar
• 15 Chopra IJ. Gonadal steroids and gonadotropins in hyperthyroidism. Med Clin North Am 1975; 59 (5) 1109-1121
  PubMedGoogle Scholar
• 16 Carani C, Isidori AM, Granata A , et al. Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients. J Clin Endocrinol Metab 2005; 90 (12) 6472-6479
  CrossrefPubMedGoogle Scholar
• 17 Krassas GE, Tziomalos K, Papadopoulou F, Pontikides N, Perros P. Erectile dysfunction in patients with hyper- and hypothyroidism: how common and should we treat?. J Clin Endocrinol Metab 2008; 93 (5) 1815-1819
  CrossrefPubMedGoogle Scholar
• 18 Krassas GE, Pontikides N, Deligianni V, Miras K. A prospective controlled study of the impact of hyperthyroidism on reproductive function in males. J Clin Endocrinol Metab 2002; 87 (8) 3667-3671
  CrossrefPubMedGoogle Scholar
• 19 Hudson RW, Edwards AL. Testicular function in hyperthyroidism. J Androl 1992; 13 (2) 117-124
  PubMedGoogle Scholar
• 20 Abalovich M, Levalle O, Hermes R , et al. Hypothalamic-pituitary-testicular axis and seminal parameters in hyperthyroid males. Thyroid 1999; 9 (9) 857-863
  CrossrefPubMedGoogle Scholar
• 21 Krassas GE, Papadopoulou F, Tziomalos K, Zeginiadou T, Pontikides N. Hypothyroidism has an adverse effect on human spermatogenesis: a prospective, controlled study. Thyroid 2008; 18 (12) 1255-1259
  CrossrefPubMedGoogle Scholar
• 22 Poppe K, Glinoer D, Tournaye H, Maniewski U, Haentjens P, Velkeniers B. Is systematic screening for thyroid disorders indicated in subfertile men?. Eur J Endocrinol 2006; 154 (3) 363-366
  CrossrefPubMedGoogle Scholar
• 23 Nikoobakht MR, Aloosh M, Nikoobakht N, Mehrsay AR, Biniaz F, Karjalian MA. The role of hypothyroidism in male infertility and erectile dysfunction. Urol J 2012; 9 (1) 405-409
  PubMedGoogle Scholar
• 24 Krassas GE, Pontikides N. Gonadal effect of radiation from 131I in male patients with thyroid carcinoma. Arch Androl 2005; 51 (3) 171-175
  PubMedGoogle Scholar
• 25 Hyer S, Vini L, O'Connell M, Pratt B, Harmer C. Testicular dose and fertility in men following I(131) therapy for thyroid cancer. Clin Endocrinol (Oxf) 2002; 56 (6) 755-758
  CrossrefPubMedGoogle Scholar
• 26 Wichers M, Benz E, Palmedo H, Biersack HJ, Grünwald F, Klingmüller D. Testicular function after radioiodine therapy for thyroid carcinoma. Eur J Nucl Med 2000; 27 (5) 503-507
  CrossrefPubMedGoogle Scholar