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Synlett 2016; 27(15): 2225-2228
DOI: 10.1055/s-0035-1561668
DOI: 10.1055/s-0035-1561668
letter
Synthesis of 5-Substituted 1H-Tetrazoles from Aldoximes Using Diphenyl Phosphorazidate
Further Information
Publication History
Received: 13 April 2016
Accepted after revision: 16 May 2016
Publication Date:
22 June 2016 (online)
Abstract
A novel method for the synthesis of 5-substituted 1H-tetrazoles using diphenyl phosphorazidate (DPPA) has been developed. Aromatic and aliphatic aldoximes underwent cycloaddition to afford the corresponding 5-substituted 1H-tetrazoles with ease and efficiency.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561668.
- Supporting Information
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- 28 General Procedure DPPA (0.30 mmol) and DBU (0.60 mmol) were added to a solution of aldoxime (0.20 mmol) in toluene (1.0 mL). After stirring for 16 h at reflux, the mixture was cooled to room temperature and sat. NaHCO3 aq (2.0 mL) was added. After stirring for 5 min, the mixture was diluted with water (20 mL). The aqueous layer was then washed with EtOAc (25 mL) and acidified with 1.0 N HCl aq to pH 2. The aqueous layer was extracted with EtOAc (2 × 30 mL), and the combined organic extracts were washed with brine (30 mL) and dried over Na2SO4. The concentration of the solvent in vacuo followed by the purification of the residue through a short silica gel column (EtOAc–n-hexane = 1:1 to 3:1) gave the desired tetrazole. Analytical Data for 5-Phenyl-1H-tetrazole (Table 2, Entry 1) White solid; mp 214 °C. 1H NMR (270 MHz, DMSO-d 6): δ = 7.60–7.66 (m, 3 H), 8.03–8.07 (m, 2 H).
- 29 Analytical data for tetrazoles are provided in the Supporting Information.
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