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Synthesis 2013; 45(23): 3269-3275
DOI: 10.1055/s-0033-1339799
paper
© Georg Thieme Verlag Stuttgart · New York

Convenient Synthesis of Benzoxazolone Derivatives by Cross-Coupling of Benzoxazolone Boronates with Aryl Halides

Takayuki Fukaya*
Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd., 33-94 Enoki, Suita, Osaka 564-0053, Japan   Fax: +81(6)63376010   Email: takayuki-fukaya@ds-pharma.co.jp
,
Shuji Masumoto
Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd., 33-94 Enoki, Suita, Osaka 564-0053, Japan   Fax: +81(6)63376010   Email: takayuki-fukaya@ds-pharma.co.jp
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Publication History

Received: 15 July 2013

Accepted after revision: 18 August 2013

Publication Date:
24 September 2013 (online)

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Abstract

Benzoxazolone derivatives with various substituents at the C-5 position were synthesized efficiently via benzoxazolone boronates as the key intermediate. The target compounds were also synthesized from (het)aryl halides in a one-pot process. These methods permitted efficient exploratory syntheses of a series of benzoxazolone derivatives.

Key words

heterocycles - boron - cross-coupling - biaryls - catalysis - arylations

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    for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
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