J Neurol Surg A Cent Eur Neurosurg 2012; 73(04): 238-242
DOI: 10.1055/s-0032-1313588
Review
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Primary Osseous Leiomyosarcoma of the Spine: A Rare Entity—Case Report and Review of the Literature[*]

M. Potsi
1   AHEPA University Hospital, Radiology Department, Thessaloniki, Greece
,
P. Stavrinou
2   AHEPA University Hospital, Neurosurgical Department, Thessaloniki, Greece
,
N. Patsinakidis
1   AHEPA University Hospital, Radiology Department, Thessaloniki, Greece
,
D. Hatzibougias
3   AHEPA University Hospital, Department of Pathology, Thessaloniki, Greece
,
N. Foroglou
2   AHEPA University Hospital, Neurosurgical Department, Thessaloniki, Greece
,
G. Karayanopoulou
3   AHEPA University Hospital, Department of Pathology, Thessaloniki, Greece
,
A. Kalogera-Founzila
1   AHEPA University Hospital, Radiology Department, Thessaloniki, Greece
› Author Affiliations
Further Information

Publication History

Publication Date:
03 May 2012 (online)

Abstract

Primary osseous leiomyosarcoma of the spine is an extremely rare entity with only 13 previous cases having been reported in the literature. We present the case of a 57-year-old woman with a tumor of the eleventh thoracic vertebra, causing compression of the spinal cord. Histopathology and immunohistochemical results of the tumor biopsy specimen disclosed a primary leiomyosarcoma of the thoracic spine. We report on the features of this rare entity but also review and summarize the imaging and pathology characteristics that can be extrapolated from the existing literature.

* This article was originally published online in Central European Neurosurgery on July 27, 2010 (DOI:10.1055/s-0030-1253409)


 
  • References

  • 1 Angervall L, Berlin O, Kindblom LG , et al. Primary leiomyosarcoma of bone: a study of five cases. Cancer 1980; 46: 1270-1279
  • 2 Antonescu CR, Erlandson RA, Huvos AG. Primary leiomyosarcoma of bone: a clinicopathologic, immunohistochemical, and ultrastructural study of 33 patients and a literature review. Am J Surg Pathol 1997; 21: 1281-1294
  • 3 Aksoy D, Altundag MK, Durusu M , et al. Thoracic paravertebral leiomyosarcoma. Spine 2002; 27: 301-303
  • 4 Boutselis JG, Ullery JC. Sarcoma of the uterus. Obstet Gynecol 1962; 20: 23
  • 5 Berlin O, Angervall L, Kindblom LG , et al. Primary leiomyosarcoma of bone: a clinical, radiographic, pathologic-anatomic, and prognostic study of 16 cases. Skeletal Radiol 1987; 16: 364-376
  • 6 Dohi O, Hattori M, Ohtani H , et al. Leiomyosarcoma of the sacral bone in a patient with a past history of resection of uterine leiomyoma. Upsala J Med Sci 2003; 108: 213-220
  • 7 Evans DMD, Sanerkin NG. Primary leiomyosarcoma of bone. J Pathol Bacteriol 1965; 90: 348-350
  • 8 Ferenczy A, Richart R, Ogakai T , et al. A comparative ultrastructural study of leiomyosarcoma, cellular leiomyoma and leiomyoma of uterus. Cancer 1971; 28: 1004-1018
  • 9 Fornasier VL, Paley D. Leiomyosarcoma in bone: primary or secondary? A case report and review of the literature. Skeletal Radiol 1983; 10: 147-153
  • 10 Ganau S, Tomas X, Mallofre C , et al. Leiomyosarcoma of sacrum: imaging and histopathologic findings. Eur Radiol 2002; 12: 35-39
  • 11 Goto T, Ishida T, Motoi N , et al. Primary leiomyosarcoma of the femur. J Orthop Sci 2002; 7: 267-273
  • 12 Sundt G, Moll C, Nidectey A , et al. Primary leiomyosarcoma of the femur. J Orthop Sci 2002; 7: 863-872
  • 13 Krepler P, Windhager R, Bretschneider W , et al. Total vertebrectomy for primary malignant tumors of the spine. J Bone Joint Surg Br 2002; 84 B: 712-715
  • 14 Lehman N, Jacobs CD, Holsten AP , et al. Primary paraspinal leiomyosarcoma invading the cervical spinal canal successfully treated with surgery, radiotherapy, and chemotherapy: case report. J Neurosurg Spine 2007; 6: 441-446
  • 15 Lo TH, van Rooij WJJ, Teepen JLJM , et al. Primary leiomyosarcoma of the spine. Neuroradiology 1995; 37: 465-467
  • 16 Marshman L, Pollock J, King A , et al. Primary extradural epithelioid leiomyosarcoma of the cervical spine: case report and literature review. Neurosurgery 2005; 57: 372-375
  • 17 Nishida J, Kato S, Shiraishi H , et al. Leiomyosarcoma of the lumbar spine. Case Report. Spine 2002; 27: 42-46
  • 18 Ochiai H, Yamakawa Y, Fukushima T , et al. Primary leiomyosarcoma of the cervical spine causing spontaneous compression fracture: report of an autopsy case. Neuropathology 2000; 20: 60-64
  • 19 Ritter AM, Amaker BH, Graham RS , et al. Central nervous system leiomyosarcoma in patients with acquired immunodeficiency syndrome: report of two cases. J Neurosurg 2000; 92: 688-692
  • 20 Sanerkin N. Primary leiomyosarcoma of the bone and its comparison with fibrosarcoma: a cytological, histological and ultrastructural study. Cancer 1979; 44: 1375-1387
  • 21 SenGupta SK, Nag S. Cervical paravertebral leiomyosarcoma mimicking a nerve sheath tumor. Human Pathology 1992; 23: 708-710
  • 22 Shapiro S. Myelopathy secondary to leiomyosarcoma of the spine. Case report. Spine 1992; 17: 249-251
  • 23 Spiro RH, Koss LG. Myosarcoma of the uterus: a clinicopathological study. Cancer 1965; 18: 571
  • 24 Takakazu S, Akihide T, Satoshi K , et al. Primary leiomyosarcoma of the vertebra: case report and review of the literature. Pathology International 2004; 54: 73-76
  • 25 Von Hochstetter AR, Eberle H, Ruttner JR. Primary leiomyosarcoma of extragnathic bones. Cancer 1984; 53: 2194-2200
  • 26 Young MP, Freemont AJ. Primary leiomyosarcoma of bone. Histopathology 1991; 19: 257-262