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Int J Sports Med 2012; 33(03): 181-185
DOI: 10.1055/s-0031-1291252
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Nandrolone Inhibits MMP-2 in the Left Ventricle of Rats

R. C. Marqueti
1   Physiological Sciences, Federal University of São Carlos, Brazil
,
K. C. Micocci
1   Physiological Sciences, Federal University of São Carlos, Brazil
,
R. D. Leite
1   Physiological Sciences, Federal University of São Carlos, Brazil
,
H. S. Selistre-de-Araujo
› Author Affiliations
Further Information

Publication History



accepted after revision 20 September 2011

Publication Date:
30 January 2012 (online)

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Abstract

The indiscriminate use of anabolic-androgenic steroids has been shown to induce left ventricular dysfunctions. The main objective of the present study was to investigate the effects of nandrolone decanoate on matrix metalloprotease (MMP-2) activity and protein level in the left ventricle (LV) of rats after 7 weeks of mechanical load exercise. Wistar rats were grouped into: sedentary (S); nandrolone decanoate-treated sedentary (AAS); trained without AAS (T) and trained and treated with AAS (AAST). Exercised groups performed a 7-weeks water-jumping program. Training significantly increased the MMP-2 activity by zymography and the protein level by Western blotting analysis. However, the AAS treatment abolished both the increase in MMP activity and protein level induced by exercise. These results suggest that AAS may impair cardiac tissue remodeling which may lead to the heart malfunction.

Key words

androgenic-anabolic steroid - left ventricle - matrix metallopeptidases - mechanical load exercise
 

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