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DOI: 10.1055/s-0030-1267953
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Effects of Metformin and Pioglitazone on Serum Pentosidine Levels in Type 2 Diabetes Mellitus
Publication History
received 02.07.2010
first decision 02.07.2010
accepted 04.08.2010
Publication Date:
06 April 2011 (online)
Abstract
Objective: Accumulation of advanced glycation end products (AGEs) is associated with age- and diabetes-related disease. The aim of the present study is to investigate the effects of metformin or pioglitazone on serum pentosidine levels, a well-defined AGE, in type 2 diabetes.
Research Design and Methods: 66 Japanese patients were enrolled in this 6 months open-label study. In the metformin (n=22), the pioglitazone (n=22), and the control (optimal diet therapy, sulfonylurea and/or insulin) groups (n=22), serum levels of HbA1c and pentosidine were measured at baseline and 6 months after each treatment.
Results: HbA1c and pentosidine levels were not different at baseline among 3 groups, and HbA1c was significantly decreased at 6 months in each group. In the metformin and the pioglitazone groups, serum pentosidine levels were significantly decreased at 6 months after treatments (p=0.039 and p=0.031, respectively). Percent changes in pentosidine levels in the metformin and the pioglitazone groups were significantly lower than that in the control group (p=0.012 and p=0.019, respectively).
Conclusion: 6 months treatments with metformin or pioglitazone in clinical doses decreased serum pentosidine levels which resulted in greater %change of serum pentosidine levels than the control group, suggesting that these agents may prevent the diabetic complications associated with AGEs accumulation.
Key words
pentosidine - metformin - pioglitazone - type 2 diabetes mellitus - advanced glycation end product
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Correspondence
I. KanazawaMD, PhD
Department of Internal
Medicine 1
Shimane University Faculty of
Medicine
89–1 Enya-cho
Izumo
693–8501 Shimane
Japan
Phone: +81/853/20 2183
Fax: +81/853/23 8650
Email: ippei.k@med.shimane-u.ac.jp