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Synthesis 2010(19): 3332-3338  
DOI: 10.1055/s-0030-1257871
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Efficient Methods for the Synthesis of Arylacetonitriles

Federica Stazi, William Maton, Damiano Castoldi, Pieter Westerduin, Ornella Curcuruto, Sergio Bacchi*
GlaxoSmithKline Spa, Chemical Development Department, Via Fleming 4, 37135 Verona, Italy
Fax: +39(045)8218117; e-Mail: sergio.k.bacchi@gsk.com;
Further Information

Publication History

Received 20 April 2010
Publication Date:
30 July 2010 (online)

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Abstract

Various approaches to [2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile were investigated. Two of these methods were selected and applied to a variety of electron-deficient substrates, thereby expanding the scopes of the procedures.

Key words

nitriles - nucleophilic aromatic substitutions - decarboxylations - Wittig reactions - reductions

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