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Exp Clin Endocrinol Diabetes 1985; 85(1): 81-88
DOI: 10.1055/s-0029-1210423
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Serum Magnesium in Insulin-Dependent Diabetics and Healthy Subjects in Relation to Insulin Secretion and Glycemia during Glucose-Glucagon Test*

R. Menzel, H. Pusch, G. W. Ratzmann1) , W. Besch, F. Förster, G. Albrecht, R. Ruhnke
  • Central Institute of Diabetes “Gerhardt Katsch” (Director: OMR Prof. Dr. sc. med. H. Bibergeil), I. Clinical Department (Director: OMR Prof. Dr. sc. med. B. Schulz), Karlsburg/GDR
* Dedicated to Professor H. Bibergeil on the Occassion of his 60th Birthday. 1) Ernst-Moritz-Arndt-University of Greifswald, GDR.
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Publication History

1984

Publication Date:
16 July 2009 (online)

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Summary

In order to investigate the influence of insulin secretion on serum magnesium concentrations 33 insulin-dependent diabetics and 10 control subjects were studied. The residual insulin secretion (BIS) was investigated by measurement of human C-peptide (HOP) before and after stimulation during on OGTT (1.75 mg/kg)-glucagon (i.v. 0.1 mg glucagon/kg)-test.

Results: Certain RIS existed in 11 insulin-dependent diabetics, 12 were without any RIS (uncertain RIS in 10 patients). Glucose tolerance and daily glycemia differed significantly among the two groups. However, all diabetics were far from euglycemia, (3.3—9.3 mmol/1): Fasting plasma glucose 12.0 ± 0.9 (certain RIS), 15.0 ± 0.8 (no RIS), 13.9 ± 1.8 (uncertain RIS). Serum magnesium was significantly lower in all diabetics, both before and during the test. There was no change during the OGTT-glucagon-test and no difference among the three groups of insulin-dependent diabetics.

So, we conclude that a small RIS in our longterm insulindependent diabetics has no influence on the behaviour of serum magnesium. But, magnesium depletion can influence coronary blood flow, blood clotting, and atherogenesis. Therefore, it should be necessary to pay more attention to the hypomagnesemia in insulin-dependent diabetics.

Key words

Magnesium - Insulin secretion - Glycemia - Diabetes

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