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Horm Metab Res 1979; 11(4): 304-306
DOI: 10.1055/s-0028-1092729
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© Georg Thieme Verlag KG Stuttgart · New York

Effects of Thyrotoxicosis on Mitochondrial Enzymes of Rat Soleus

J. B. Courtright , R. H. Fitts
  • Department of Biology Marquette University, Milwaukee, Wisconsin, U.S.A.
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Publication Date:
17 December 2008 (online)

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Abstract

Cytochrome oxidase, glycerol-3-phosphate dehydrogenase, and succinate dehydrogenase were measured in mitochondrial fractions obtained from rat soleus muscle of control and 8 week T3 + T4 treated animals. Under these conditions of prolonged treatment, there is a five-fold increase in the specific activities of both cytochrome oxidase and glycerols-3-phosphate dehydrogenase. Significant increases in total cellular mitochondrial content and enzyme activities were observed in T3 + T4 treated animals as compared to controls. These results indicate that thyrotoxicosis can induce selective changes in mitochondrial enzymes in slow twitch red (Type I) muscle fibers.

Key words

Thyrotoxicosis - Mitochondrial Enzymes - Rat Soleus Muscle

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