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Synthesis 2009(6): 941-944  
DOI: 10.1055/s-0028-1087981
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A One-Pot Method for the Iodination of Aryl Amines via Stable Aryl Diazonium Silica Sulfates Under Solvent-Free Conditions

Amin Zarei*a,b, Abdol R Hajipourc,d, Leila Khazdoozd
a Department of Science, Islamic Azad University, Fasa Branch, Post Box No 364, Fasa, 7461713591 Fars, Iran
Fax: +98(731)3333411; e-Mail: aj_zarei@yahoo.com;
b Fasa Higher Education Institute, Fasa, 7461781189 Fars, Iran
c Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, WI 53706-1532, USA
d Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, 84156 Isfahan, Iran
Further Information

Publication History

Received 18 August 2008
Publication Date:
02 March 2009 (online)

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Abstract

A convenient and rapid one-pot method for the synthesis of iodoarenes is developed which involves the sequential diazotization-iodination of aromatic amines with sodium nitrite, silica sulfuric acid and potassium iodide under solvent-free conditions at room temperature. Various aromatic amines possessing electron-withdrawing groups or electron-donating groups are converted into the corresponding aryl iodides in good yields.

Key words

diazotization-iodination - aromatic amines - iodo­arenes - silica sulfuric acid

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