Pädiatrische Rhinologie

 

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Zusammenfassung

Der folgende Übersichtsartikel beleuchtet Schwerpunkte der pädiatrischen Rhinologie, die aktuell in der Wissenschaft und auf Tagungen sowie in der interdisziplinären Diskussion zwischen Hals-Nasen-Ohren-Heilkunde und Pädiatrie federführend thematisiert werden. Im Speziellen werden angeborene Fehlbildungen wie die Choanalatresie oder die nasalen Dermoidzysten diskutiert. Des Weiteren folgt eine Stellungnahme zum aktuellen Vorgehen bei sinugenen orbitalen Komplikationen sowie zur Diagnostik und Therapie der chronischen Rhinosinusitis bei Kindern. Im Besonderen folgen Updates zur Aufgabe des Hals-Nasen-Ohren-Arztes bei der Betreuung von Kindern mit zystischer Fibrose und Primärer Ziliendyskinesie.

Publication History

Article published online:
02 May 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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• Literatur

• 1 Rahbar R, Shah P, Mulliken JB, Robson CD, Perez-Atayde AR, Proctor MR, Kenna MA, Scott MR, McGill TJ, Healy GB. The presentation and management of nasal dermoids: a 30-year experience. Arch Otloaryngol Head Neck Surg 2003; 129: 464-471 DOI: 10.1001/archotol.129.4.464.
  CrossrefPubMedGoogle Scholar
• 2 Ortlib T, Ambro BT, Pereira KD. Midline approach to pediatric nasofrontal dermoid cysts. JAMA Otolaryngol Head Neck Surg 2015; 141: 174-177 DOI: 10.1001/jamaoto.2014.3185.
  CrossrefPubMedGoogle Scholar
• 3 Hartley BEJ, Eze N, Trozzi M, Toma S, Hewitt R, Jephson C, Cochrane L, Wyatt M, Albert D. Nasal dermoids in children: a proposal for a new classification based on 103 cases at Great Ormond Street Hospital. Int J Pediatr Otorhinolaryngol 2015; 79: 18-22 DOI: 10.1016/j.ijporl.2014.10.020.
  CrossrefPubMedGoogle Scholar
• 4 El-Fattah AMA, Naguib A, El-Sisi H, Kamal E, Tawfik A. Midline nasofrontal dermoids in children: a review of 29 cases managed at Mansoura University Hospitals. Int J Pediatr Otorhinolaryngol 2016; 83: 88-92 DOI: 10.1016/j.ijporl.2016.01.005.
  CrossrefPubMedGoogle Scholar
• 5 Kotowski M, Szydlowski J. Radiological diagnostics in nasal dermoids: pittfalls, predictive values and literature analysis. Int J Pediatr Otorhinolaryngol 2021; 149: 110842 DOI: 10.1016/j.ijporl.2021.110842.
  CrossrefPubMedGoogle Scholar
• 6 Pierce CA, Komofaos P, Alvarez S, Wallace RD. Excision and fat grafting of nasal tip dermoid cysts through an open rhinoplasty approach. J Craniofacial Surg 2016; 27: e18-e20 DOI: 10.1097/SCS.0000000000002291.
  CrossrefPubMedGoogle Scholar
• 7 Carroll WW, Farhood Z, White DR, Patel KG. Nasal dorsum reconstruction after pediatric nasal dermoid excision. Int J Pediatr Otorhinolaryngol 2021; 140: 110502 DOI: 10.1016/j.ijporl.2020.110502.
  CrossrefPubMedGoogle Scholar
• 8 Deutsch E, Kaufman M, Eilon A. Transnasal endoscopic management of choanal atresia. Int J Pediatr Otorhinolaryngol 1997; 40: 19-26 DOI: 10.1016/s0165-5876(96)01486-3.
  CrossrefPubMedGoogle Scholar
• 9 Josephson GD, Vickery CL, Giles WC, Gross CW. Transnasal endoscopic repair of congenital choanal atresia: long-term results. Arch Otolaryngol Head Neck Surg 1998; 124: 537-540 DOI: 10.1001/archotol.124.5.537.
  CrossrefPubMedGoogle Scholar
• 10 Hengerer AS, Brickman TM, Jeyakumar A. Choanal atresia: embryologic analysis and evolution of treatment, a 30-year experience. Laryngoscope 2008; 118: 862-866 DOI: 10.1097/MLG.0b013e3181639b91.
  CrossrefPubMedGoogle Scholar
• 11 Baumann I, Sommerburg O, Amrhein P, Plinkert PK, Koitschev A. Diagnostik und Management der Choanalatresie. HNO 2018; 66: 329-338 DOI: 10.1007/s00106-018-0492-7.
  CrossrefPubMedGoogle Scholar
• 12 Jung H. Die angeborene Choanalatresie und deren operative Korrektur. Laryngorhinootologie 1994; 73: 586-590 DOI: 10.1055/s-2007-997201.
  Article in Thieme ConnectPubMedGoogle Scholar
• 13 Kwong KM. Current updates on choanal atresia. Front Pediatr 2015; 3: 52 DOI: 10.3389/fped.2015.00052.
  CrossrefPubMedGoogle Scholar
• 14 Pagon RA, Graham JM, Zonana J, Yong SL. Coloboma, congenital heart disease, and choanal atresia with multiple anomalies: CHARGE association. J Pediatr 1981; 99: 223-227 DOI: 10.1016/s0022-3476(81)80454-4.
  CrossrefPubMedGoogle Scholar
• 15 Harris J, Robert E, Källén B. Epidemiology of choanal atresia with special reference to the CHARGE association. Pediatrics 1997; 99: 363-367 DOI: 10.1542/peds.99.3.363.
  CrossrefPubMedGoogle Scholar
• 16 Burrow TA, Saal HM, de Alarcon A, Martin LJ, Cotton RT, Hopkin RJ. Characterization of congenital anomalies in individuals with choanal atresia. Arch Otolaryngol Head Neck Surg 2009; 135: 543-547 DOI: 10.1001/archoto.2009.53.
  CrossrefPubMedGoogle Scholar
• 17 Cedin AC, Atallah AN, Andriolo RB, Cruz OL, Pignatari SN. Surgery for congenital choanal atresia. Cochrane Database Syst Rev 2012; CD008993 DOI: 10.1002/14651858.CD008993.pub2.
  CrossrefPubMedGoogle Scholar
• 18 Urbančič J, Vozel D, Battelino S, Boršoš I, Bregant L, Glavan M, Iglič Č, Jenko K, Lanišnik B, Soklič Košak T. Management of Choanal Atresia: National Recommendations with a Comprehensive Literature Review. Children (Basel) 2023; 10: 91 DOI: 10.3390/children10010091.
  CrossrefPubMedGoogle Scholar
• 19 Riepl R, Scheitauer M, Hoffmann TK, Rotter N. Transnasal endoscopic treatment of bilateral choanal atresia in newborns using balloon dilatation: own results and review of literature. Int J Pediatr Otorhinolaryngol 2014; 78: 459-464 DOI: 10.1016/j.ijporl.2013.12.017.
  CrossrefPubMedGoogle Scholar
• 20 Moreddu E, Rizzi M, Adil E. et al. International Pediatric Otolaryngology Group (IPOG) consensus recommendations: Diagnosis, pre-operative, operative and post-operative pediatric choanal atresia care. Int J Pediatr Otorhinolaryngol 2019; 123: 151-155 DOI: 10.1016/j.ijporl.2019.05.010.
  CrossrefPubMedGoogle Scholar
• 21 Lau K, Stavrakas M, Ray J. Lasers in Rhinology-An Update. Ear Nose Throat J 2021; 100: 77S-82S DOI: 10.1177/0145561320940115.
  CrossrefPubMedGoogle Scholar
• 22 De Vinventiis GC, Panatta ML, De Corso E, Marini G, Bianchi A, Giuliani M, Sitzia E, Tucci FM. Endoscopic treatment of choanal atresia and use of balloon dilation: our experience. Acta Otorhinolaryngol Ital 2020; 40: 44-49 DOI: 10.14639/0392-100X-1567.
  CrossrefPubMedGoogle Scholar
• 23 Alsubaie HM, Almosa WH, Al-Qahtani AS, Margalani O. Choanal Atresia Repair With Stents and Flaps: A Systematic Review Article. Allergy Rhinol (Providence) 2021; 12 21526567211058052 DOI: 10.1177/21526567211058052.
  CrossrefPubMedGoogle Scholar
• 24 Strychowsky JE, Kawai K, Moritz E, Rahbar R, Adil EA. To stent or not to stent? A meta-analysis of endonasal congenital bilateral choanal atresia repair. Laryngoscope 2016; 126: 218-227 DOI: 10.1002/lary.25393.
  CrossrefPubMedGoogle Scholar
• 25 Sung JY, Cho KS, Bae YC, Bae SH. Image-guided navigation surgery for bilateral choanal atresia with a Tessier number 3 facial cleft in an adult. Arch Craniofac Surg 2020; 21: 64-68 DOI: 10.7181/acfs.2019.00661.
  CrossrefPubMedGoogle Scholar
• 26 Rodríguez H, Cuestas G, Passali D. A 20-year experience in microsurgical treatment of choanal atresia. Acta Otorrinolaringol Esp 2014; 65: 85-92 DOI: 10.1016/j.otorri.2013.09.005.
  CrossrefPubMedGoogle Scholar
• 27 Gundle L, Ojha S, Hendry J, Rosen H. Stenting versus stentless repair for bilateral choanal atresia: A systematic review of the literature. Int J Pediatr Otorhinolaryngol 2021; 151: 110926 DOI: 10.1016/j.ijporl.2021.110926.
  CrossrefPubMedGoogle Scholar
• 28 Carter JM, Lawlor C, Guarisco JL. The efficacy of mitomycin and stenting in choanal atresia repair: a 20 year experience. In J Pediatr Otorhinolaryngol 2014; 78: 307-311 DOI: 10.1016/j.ijporl.2013.11.031.
  CrossrefPubMedGoogle Scholar
• 29 Kapadia MK, Freitag SK, Woog JJ. Evaluation and management of congenital nasolacrimal duct obstruction. Otolaryngol Clin North Am 2006; 39: 959-977 vii DOI: 10.1016/j.otc.2006.08.004.
  CrossrefPubMedGoogle Scholar
• 30 Gupta AK, Bansal S. Primary endoscopic dacryocystorhinostomy in children-analysis of 18 patients. Int J Pediatr Otorhinolaryngol 2006; 70: 1213-1217 DOI: 10.1016/j.ijporl.2005.12.016.
  CrossrefPubMedGoogle Scholar
• 31 Eloy P, Leruth E, Cailliau A, Collet S, Bertrand B, Rombaux P. Pediatric endonasal endoscopic dacryocystorhinostomy. Int J Pediatr Otorhinolaryngol 2009; 73: 867-871 DOI: 10.1016/j.ijporl.2009.03.006.
  CrossrefPubMedGoogle Scholar
• 32 Gioacchini FM, Alicandri-Ciufelli M, Kaleci S, Re M. The outcomes of endoscopic dacryocystorhinostomy in children: A systematic review. Int J Pediatr Otorhinolaryngol 2015; 79: 947-952 DOI: 10.1016/j.ijporl.2015.04.023.
  CrossrefPubMedGoogle Scholar
• 33 Leone CR, Van Gemert JV. The success rate of silicone intubation in congenital lacrimal obstruction. Ophthalmic Surg 1990; 21: 90-92
  PubMedGoogle Scholar
• 34 Zloto O, Koval T, Yakirevich A, Ben Simon GJ, Weissman A, Ben Artsi E, Ben Shoshan J, Priel A. Endoscopic dacryocystorhinostomy with and without mucosal flap-is there any difference?. Eye (Lond) 2020; 34: 1449-1453 DOI: 10.1038/s41433-019-0716-4.
  CrossrefPubMedGoogle Scholar
• 35 Vanderveen DK, Jones DT, Tan H, Petersen RA. Endoscopic dacryocystorhinostomy in children. J AAPOS 2001; 5: 143-147 DOI: 10.1067/mpa.2001.114910.
  CrossrefPubMedGoogle Scholar
• 36 Berlucchi M, Staurenghi G, Brunori PR, Tomenzoli D, Nicolai P. Transnasal endoscopic dacryocystorhinostomy for the treatment of lacrimal pathway stenoses in pediatric patients. Int J Pediatr Otorhinolaryngol 2003; 67: 1069-1074 DOI: 10.1016/s0165-5876(03)00188-5.
  CrossrefPubMedGoogle Scholar
• 37 Bernal-Sprekelsen M, Massegur Solench H, Tomás Barberán M. Paediatric endoscopic sinus surgery (PESS): review of the indications. Rev Laryngol Otol Rhinol (Bord) 2003; 124: 145-150
  PubMedGoogle Scholar
• 38 Nitin T, Uddin S, Paul G. Enddonasal endoscopic dacrycystorhinostomy with and without stents – a comparative study. Indian J Otolaryngol Head Neck Surg 2022; 74: 1433-1441 DOI: 10.1007/s12070-021-02561-5.
  CrossrefPubMedGoogle Scholar
• 39 Cheng S, Feng Y, Xu L, Li Y, Huang J. Efficacy of mitomycin C in endoscopic dacryocystorhinostomy: a systematic review and meta-analysis. PLoS One 2013; 13: e62737 DOI: 10.1371/journal.pone.0062737.
  CrossrefPubMedGoogle Scholar
• 40 Saniasiaya J, Abdullah B, Husain S, Wang DY, Mohammad ZW. Primary endoscopic endonasal dacryocystorhinostomy for pediatric nasolacrimal duct obstruction: A systematic review. Am J Rhinol Allergy 2017; 31: 328-333 DOI: 10.2500/ajra.2017.31.4464.
  CrossrefPubMedGoogle Scholar
• 41 Stenner M, Rudack C. Erkrankungen der Nase und der Nasennebenhöhlen im Kindesalter. Laryngo-Rhino-Otol 2014; 93: S24-S48 DOI: 10.10055/s-0033-1363211.
  CrossrefPubMedGoogle Scholar
• 42 Kais A, Chaiban R, Makary AC, Ramadan HH. Seasonal variations, acute rhinosinusitis and orbital infections in children. Am J Otolaryngol 2023; 44: 103918 DOI: 10.1016/j.amjoto.2023.103918.
  CrossrefPubMedGoogle Scholar
• 43 Chandler JR, Langenbrunner DJ, Stevens ER. The pathogenesis of orbital complications in acute sinusitis. Laryngoscope 1970; 80: 1414-1428
  CrossrefPubMedGoogle Scholar
• 44 Sobol SE, Marchand J, Tewfik TL, Manoukian JJ, Schloss MD. Orbital complications of sinusitis in children. J Otolaryngol 2002; 31: 131-136 DOI: 10.2310/7070.2002.10979.
  CrossrefPubMedGoogle Scholar
• 45 Al-Madani MV, Khatatbeh AE, Rawashdeh RZ, Al-Khtoum NF, Shawagfeh NR. The prevalence of orbital complications among children and adults with acute rhinosinusitis. Braz J Otorhinolaryngol 2013; 79: 716-719 DOI: 10.5935/1808-8694.20130131.
  CrossrefPubMedGoogle Scholar
• 46 Santos JC, Pinto S, Ferreira S, Maia C, Alves S, da Silva V. Pediatric preseptal and orbital cellulitis: A 10-year experience. Int J Pediatr Otorhinolaryngol 2019; 120: 82-88 DOI: 10.1016/j.ijporl.2019.02.003.
  CrossrefPubMedGoogle Scholar
• 47 Knipping S, Hirt J, Hirt R. Management of orbital complications. Laryngo-Rhino-Otol 2015; 94: 819-826 DOI: 10.1055/s-0035-1547285.
  Article in Thieme ConnectPubMedGoogle Scholar
• 48 Miranda-Barrios J, Bravo-Queipo-de-Llano B, Baquero-Artigao F, Granados-Fernandez M, Noval S, Rabanal I, Méndez-Echevarría A, Del Rosal T, Sainz T, Aracil J, Calvo C. Preseptal Versus Orbital Cellulitis in Children: An Observational Study. Pediatr Infect Dis J 2021; 40: 969-974 DOI: 10.1097/INF.0000000000003226.
  CrossrefPubMedGoogle Scholar
• 49 Orman G, Kralik SF, Desai N, Meoded A, Vallejo JG, Huisman TAGM, Tran BH. Imaging of Paranasal Sinus Infections in Children: A Review. J Neuroimaging 2020; 30: 572-586 DOI: 10.1111/jon.12737.
  CrossrefPubMedGoogle Scholar
• 50 Trottier ED, St-Armand BF, Vincent M, Chevalier I, Autmizguine J, Tremblay S, Gouin S. Outpatient management of moderate cellulitis in children using high-dose oral cephalexin. Paediatr Child Health 2022; 27: 213-219 DOI: 10.1093/pch/pxac031.
  CrossrefPubMedGoogle Scholar
• 51 Raponi I, Giovannetti F, Buracchi M, Priore P, Battisti A, Scagnet M, Genitori L, Valentini V. Management of orbital and brain complications of sinusitis: A practical algorithm. J Craniomaxillofac Surg 2021; 49: 1124-1129 DOI: 10.1016/j.jcms.2021.09.005.
  CrossrefPubMedGoogle Scholar
• 52 Welkoborsky HJ, Pitz S, Grass S, Breuer B, Holte APV, Bertram O, Wiechens B. Sinogenic orbital complications. Dtsch Arztebl Int 2022; 119: 31-37 DOI: 10.3238/arztebl.m2021.0379.
  CrossrefPubMedGoogle Scholar
• 53 McDermott SM, Onwuka A, Elmaraghy C, Walz PC. Management Patterns in Pediatric Complicated Sinusitis. Otolaryngol Head Neck Surg 2020; 163: 814-821 DOI: 10.1177/0194599820918832.
  CrossrefPubMedGoogle Scholar
• 54 Welkoborsky HJ, Graß S, Deichmüller C, Bertram O, Hinni ML. Orbital complications in children: differential diagnosis of a challenging disease. Eur Arch Otorhinolaryngol 2015; 272: 1157-1163 DOI: 10.1007/s00405-014-3195-z.
  CrossrefPubMedGoogle Scholar
• 55 Nageswaran S, Woods CR, Benjamin DK, Givner LB, Shetty AK. Orbital cellulitis in children. Pediatr Infect Dis J 2006; 25: 695-699 DOI: 10.1097/01.inf.0000227820.36036.f1.
  CrossrefPubMedGoogle Scholar
• 56 Zhao EE, Koochakzadeh S, Nguyen SA, Yoo F, Pecha P, Schlosser RJ. Orbital complications of acute bacterial rhinosinusitis in the pediatric population: a systematic review and meta-analysis. Int J Pediatr Otorhinolaryngol 2020; 135: 110078 DOI: 10.1016/j.ijporl.2020.110078.
  CrossrefPubMedGoogle Scholar
• 57 Sinclair CF, Berkowitz RG. Prior antibiotic therapy for acute sinusitis in children and the development of subperiosteal orbital abscess. Int J Pediatr Otorhinolaryngol 2007; 71: 1003-1006 DOI: 10.1016/j.ijporl.2007.02.013.
  CrossrefPubMedGoogle Scholar
• 58 Chrobok V, Pellant A, Mandysova P, Mejzlik J, Dedkova J, Celakovsky P. Rhinogenic orbital inflammation-what has changed over the past 50 years?. Acta Medica (Hradec Kralove) 2019; 62: 94-98 DOI: 10.14712/18059694.2019.131.
  CrossrefPubMedGoogle Scholar
• 59 Sharma S, Josephson GD. Orbital complications of acute sinusitis in infants: a systematic review and report of a case. JAMA Otolaryngol Head Neck Surg 2014; 140: 1070-1073 DOI: 10.1001/jamaoto.2014.2326.
  CrossrefPubMedGoogle Scholar
• 60 Badr DT, Gaffin JM, Phipatanakul W. Pediatric rhinosinusitis. Curr Treat Options Allergy 2016; 3: 268-281 DOI: 10.1007/s40521-016-0096-y.
  CrossrefPubMedGoogle Scholar
• 61 Heath J, Hartzell L, Putt C, Kennedy JL. Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management. Curr Allergy Asthma Rep 2018; 29: 37 DOI: 10.1007/s11882-018-0792-8.
  CrossrefPubMedGoogle Scholar
• 62 Sidell D, Shapiro NL, Bhattacharyya N. Obesity and the risk of chronic rhnisinusitis, allergic rhinitis and acute otitis media in school-age children. Laryngoscope 2013; 123: 2360-2363 DOI: 10.1002/lary.24038.
  CrossrefPubMedGoogle Scholar
• 63 Westman M, Stjärne P, Bergström A, Kull I, Toskala E, Cardell LO, Wickman M, Holmström M. Chronic rhinosinusitis is rare but bothersome in adolescents from a Swedish population-based cohort. J Allery Clin Immunol 2015; 136: 512-514 DOI: 10.1016/j.jaci.2015.02.019.
  CrossrefPubMedGoogle Scholar
• 64 Orb Q, Curtin K, Oakley GM, Wong J, Meier J, Orlandi RR, Alt JA. Familial risk of pediatric chronic rhinosinusitis. Laryngoscope 2016; 126: 739-745 DOI: 10.1002/lary.25469.
  CrossrefPubMedGoogle Scholar
• 65 Purkey MT, Li J, Mentsch F, Grant SFA, Desrosiers M, Hakonarson H, Toskala E. Genetic variation in genes encoding airway epithelial potassium channels is associated with chronic rhinosinusitis in a pediatric population. PLoS One 2014; 9: e89329 DOI: 10.1371/journal.pone.0089329.
  CrossrefPubMedGoogle Scholar
• 66 BuSaba NY, Cunningham MJ. Connexin 26 and 30 genes mutations in patients with chronic rhinosinusitis. Laryngoscope 2008; 118: 310-313 DOI: 10.1097/MLG.0b013e31815744b6.
  CrossrefPubMedGoogle Scholar
• 67 Haruna S, Sawada K, Nakajima T, Moriyama H. Relationship between pediatric sinusitis and middle turbinate pneumatization–ethmoidal sinus pyocele thought to be caused by middle turbinate pneumatization. Int J Pediatr Otorhinolaryngol 2005; 69: 375-379 DOI: 10.1016/j.ijporl.2004.11.002.
  CrossrefPubMedGoogle Scholar
• 68 Al-Qudah M. The relationship between anatomical variations of the sino-nasal region and chronic sinusitis extension in children. Int J Pediatr Otorhinolaryngol 2008; 72: 817-821 DOI: 10.1016/j.ijporl.2008.02.006.
  CrossrefPubMedGoogle Scholar
• 69 Reh DD, Higgins TS, Smith TL. Impact of tobacco smoke on chronic rhinosinusitis: a review of the literature. Int Forum Allergy Rhinol 2012; 2: 362-369 DOI: 10.1002/alr.21054.
  CrossrefPubMedGoogle Scholar
• 70 Ramadan HH. Surgical management of chronic sinusitis in children. Laryngoscope 2004; 114: 2103-2109 DOI: 10.1097/01.mlg.0000149441.28231.0c.
  CrossrefPubMedGoogle Scholar
• 71 Siedek V, Stelter K, Betz CS, Berghaus A, Leunig A. Functional endoscopic sinus surgery–a retrospective analysis of 115 children and adolescents with chronic rhinosinusitis. Int J Pediatr Otorhinolaryngol 2009; 73: 741-745 DOI: 10.1016/j.ijporl.2009.01.019.
  CrossrefPubMedGoogle Scholar
• 72 Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S. et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology 2020; 29: 1-464 DOI: 10.4193/Rhin20.600.
  CrossrefPubMedGoogle Scholar
• 73 Bettadahalli V, Chakravarti A. Post-adenoidectomy quality of life in children with refractory chronic rhinosinusitis. J Laryngol Otol 2017; 131: 773-778 DOI: 10.1017/S002221511700113X.
  CrossrefPubMedGoogle Scholar
• 74 Ramadan HH, Makary CA. Can computed tomography score predict outcome of adenoidectomy for chronic rhinosinusitis in children. Am J Rhinol Allergy 2014; 28: e80-e81 DOI: 10.2500/ajra.2014.28.4004.
  CrossrefPubMedGoogle Scholar
• 75 Ickrath P, Morbach H, Schwaneck EC, Gehrke T, Scherzad A, Hagen R, Hackenberg S. Recurrent infections of the upper aerodigestive tract in patients with primary immunodeficiency. HNO 2019; 67: 819-824 DOI: 10.1007/s00106-019-0683-x.
  CrossrefPubMedGoogle Scholar
• 76 Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, Kim KP, Howe NL, Ronckers CM, Rajaraman P, Sir Craft AW, Parker L, Berrington de González A. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet 2012; 380: 499-505 DOI: 10.1016/S0140-6736(12)60815-0.
  CrossrefPubMedGoogle Scholar
• 77 Hill M, Bhattacharyya N, Hall TR, Lufkin R, Shapiro NL. Incidental paranasal sinus imaging abnormalities and the normal Lund score in children. Otolaryngol Head Neck Surg 2004; 130: 171-175 DOI: 10.1016/j.otohns.2003.11.006.
  CrossrefPubMedGoogle Scholar
• 78 Hummel T, Bensafi M, Nikolaus J, Knecht M, Laing DG, Schaal B. Olfactory function in children assessed with psychophysical and electrophysiological techniques. Behav Brain Res 2007; 180: 133-138 DOI: 10.1016/j.bbr.2007.02.040.
  CrossrefPubMedGoogle Scholar
• 79 Don DM, Yellon RF, Casselbrant ML, Bluestone CD. Efficacy of a stepwise protocol that includes intravenous antibiotic therapy for the management of chronic sinusitis in children and adolescents. Arch Otolaryngol Head Neck Surg 2001; 12: 1093-1098 DOI: 10.1001/archotol.127.9.1093.
  CrossrefPubMedGoogle Scholar
• 80 Chong LY, Head K, Hopkins C, Philpott C, Burton MJ, Schilder AG. Different types of intranasal steroids for chronic rhinosinusitis. Cochrane Database Syst Rev 2016; 4: CD011993 DOI: 10.1002/14651858.CD011993.pub2.
  CrossrefPubMedGoogle Scholar
• 81 Ozturk F, Bakirtas A, Ileri F, Turktas I. Efficacy and tolerability of systemic methylprednisolone in children and adolescents with chronic rhinosinusitis: a double-blind, placebo-controlled randomized trial. J Allergy Clin Immunol 2011; 128: 348-352 DOI: 10.1016/j.jaci.2011.04.045.
  CrossrefPubMedGoogle Scholar
• 82 Shoseyov D, Bibi H, Shai P, Shoseyov N, Shazberg G, Hurvitz H. Treatment with hypertonic saline versus normal saline nasal wash of pediatric chronic sinusitis. J Allergy Clin Immonol 1998; 101: 602-605 DOI: 10.1016/S0091-6749(98)70166-6.
  CrossrefPubMedGoogle Scholar
• 83 Beswick DM, Messner AH, Hwang PH. Pediatric Chronic Rhinosinusitis Management in Rhinologists and Pediatric Otolaryngologists. Ann Otol Rhinol Laryngol 2017; 126: 634-639 DOI: 10.1177/0003489417719717.
  CrossrefPubMedGoogle Scholar
• 84 Jeffe JS, Bhushan B, Schroeder JW. Nasal saline irrigation in children: a study of compliance and tolerance. Int J Pediatr Otorhinolaryngol 2012; 76: 409-413 DOI: 10.1016/j.ijporl.2011.12.022.
  CrossrefPubMedGoogle Scholar
• 85 Brietzke SE, Brigger MT. Adenoidectomy outcomes in pediatric rhinosinusitis: a meta-analysis. Int J Pediatr Otorhinolaryngol 2008; 72: 1541-1545 DOI: 10.1016/j.ijporl.2008.07.008.
  CrossrefPubMedGoogle Scholar
• 86 Brietzke SE, Shin JJ, Choi S, Lee JT, Parikh SR, Pena M, Prager JD, Ramadan H, Veling M, Corrigan M, Rosenfeld RM. Clinical consensus statement: pediatric chronic rhinosinusitis. Otolaryngol Head Neck Surg 2014; 151: 542-553 DOI: 10.1177/0194599814549302.
  CrossrefPubMedGoogle Scholar
• 87 Lusk RP, Bothwell MR, Piccirillo J. Long-term follow-up for children treated with surgical intervention for chronic rhinosinusitis. Laryngoscope 2006; 116: 2099-2107 DOI: 10.1097/01.mlg.0000244387.11129.a0.
  CrossrefPubMedGoogle Scholar
• 88 Jiang XJ, Guo XY, Yuan W, Li Q, Zhong C, Jiang Z, Xiang ZL, Li TJ, Wei Y, Zhang X. Long-term improvements in quality of life after functional endoscopic sinus surgery for adolescents with chronic rhinosinusitis. Acta Otolaryngol 2012; 132: 798-802 DOI: 10.3109/00016489.2012.668709.
  CrossrefPubMedGoogle Scholar
• 89 Cornet ME, Georgalas C, Reinartz SM, Fokkens WJ. Long-term results of functional endoscopic sinus surgery in children with chronic rhinosinusitis with nasal polyps. Rhinology 2013; 51: 328-334 DOI: 10.4193/Rhino13.079.
  CrossrefPubMedGoogle Scholar
• 90 Simmonds JC, Paz-Lansberg M, Scangas G, Metson R. Endoscopic sinus surgery for chronic rhinosinusitis: 22-item Sino-Nasal Outcome Test 5-year results. Int Forum Allergy Rhinol 2022; 12: 257-265 DOI: 10.1002/alr.22886.
  CrossrefPubMedGoogle Scholar
• 91 Younis RT. The pros and cons of second-look sinonasal endoscopy after endoscopic sinus surgery in children. Arch Otolaryngol Head Neck Surg 2005; 131: 267-269 DOI: 10.1001/archotol.131.3.267.
  CrossrefPubMedGoogle Scholar
• 92 Wang PP, Ge WT, Ni X, Tang LX, Zhang J, Yang XJ, Sun JH. Endoscopic Treatment of Isolated Sphenoid Sinus Disease in Children. Ear Nose Throat J 2019; 98: 425-430 DOI: 10.1177/0145561319841227.
  CrossrefPubMedGoogle Scholar
• 93 Clement WA, Sooby P, Doherty C, Qayyum N, Irwin G. Acute isolated sphenoid sinusitis in children: A case series and systematic review of the literature. Int J Pediatr Otorhinolaryngol 2021; 140: 110492 DOI: 10.1016/j.ijporl.2020.110492.
  CrossrefPubMedGoogle Scholar
• 94 You W, Lin ZR, Wang YZ, Wang WW, Lin RS, Qiu SQ, Guo AS. Analysis of the Causes and Experience in the Diagnosis and Treatment of Meningocele Caused by Sternberg’s Canal of the Sphenoid Sinus: Two Case Reports and a Review of the Literature. Curr Med Imaging 2023; 19: 1063-1070 DOI: 10.2174/1573405619666230206103036.
  CrossrefPubMedGoogle Scholar
• 95 Bahadir O, Bahadir A, Kosucu P, Livaoglu M. The effect of maxillary sinus surgery on its development. Acta Otolaryngol 2008; 128: 551-555 DOI: 10.1080/00016480701596039.
  CrossrefPubMedGoogle Scholar
• 96 Lee S, Fernandez J, Mirjalili SA, Kirkpatrick J. Pediatric paranasal sinuses-Development, growth, pathology, & functional endoscopic sinus surgery. Clin Anat 2022; 35: 745-761 DOI: 10.1002/ca.23888.
  CrossrefPubMedGoogle Scholar
• 97 Odat H, Almardeeni D, Tanash M, Al-Qudah M. Anatomical variation of the sphenoid sinus in paediatric patients and its association with age and chronic rhinosinusitis. J Laryngol Otol 2019; 133: 482-486 DOI: 10.1017/S0022215119000653.
  CrossrefPubMedGoogle Scholar
• 98 Pyrhönen K, Kulmala P. Atopic diseases of the parents predict the offspring’s atopic sensitization and food allergy. Pediatr Allergy Immunol 2021; 32: 859-871 DOI: 10.1111/pai.13462.
  CrossrefPubMedGoogle Scholar
• 99 Scadding GK, Smith PK, Blaiss M, Roberts G, Hellings PW, Gevaert P, Mc Donald M, Sih T, Halken S, Zieglmayer PU, Schmid-Grendelmeier P, Valovirta E, Pawankar R, Wahn U. 2021; Allergic Rhinitis in Childhood and the New EUFOREA Algorithm. Front Allergy 2: 706589 DOI: 10.3389/falgy.2021.706589.
  CrossrefPubMedGoogle Scholar
• 100 Thamm R, Poethko-Müller C, Hüther A, Thamm M. RKI- Journal of Health Monitoring 2018; 3 DOI: 10.17886/RKI-GBE-2018-075.
  CrossrefPubMed
• 101 Keller T, Hohmann C, Standl M, Wijga AH, Gehring U, Melén E. et al. The sex-shift in single disease and multimorbid asthma and rhinitis during puberty – a study by MeDALL. Allergy 2018; 73: 602-614 DOI: 10.1111/all.13312.
  CrossrefPubMedGoogle Scholar
• 102 Bergmann KC, Heinrich J, Niemann H. Current status of allergy prevalence in Germany. Position paper of the Environmental Medicine Commission of the Robert Koch Institute. Allergo J Int 2016; 25: 6-10 DOI: 10.1007/s40629-016-0089-1.
  CrossrefPubMedGoogle Scholar
• 103 Bousquet J, Schünemann HJ, Togias A. et al. Allergic Rhinitis and Its Impact on Asthma Working Group. Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence. J Allergy Clin Immunol 2020; 145: 70-80 DOI: 10.1016/j.jaci.2019.06.049.
  CrossrefPubMedGoogle Scholar
• 104 Wise SK, Damask C, Roland LT. et al. International consensus statement on allergy and rhinology: Allergic rhinitis – 2023. Int Forum Allergy Rhinol 2023; 13: 293-859 DOI: 10.1002/alr.23090.
  CrossrefPubMedGoogle Scholar
• 105 Kleine-Tebbe J, Ballmer-Weber B, Beyer K, Erdmann S, Fuchs T, Henzgen M, Huttegger I, Jappe U, Jäger L, Lepp U, Niggemann B, Raithel M, Reese M, Saloga J, Szépfalusi Z, Vieths S, Worm M, Zuberbier T, Werfel T. Leitlinie: In-vitro-Diagnostik und molekulare Grundlagen von IgE-vermittelten Nahrungsmittelallergien. Allergo J 2009; 18: 132-146
  PubMedGoogle Scholar
• 106 Gureczny T, Heindl B, Klug L, Wantke F, Hemmer W, Wöhrl S. Allergy screening with extract-based skin prick tests demonstrates higher sensitivity over in-vitro molecular allergy testing. Clin Transl Allergy 2023; e12220 DOI: 10.1002/clt2.12220GURECZNYETAL.-9of9.
  CrossrefPubMedGoogle Scholar
• 107 Cuevas M, Polk ML, Becker S, Huppertz T, Hagemann J, Bergmann C, Wrede H, Schlenter W, Haxel B, Bergmann KC, Klimek L. Rhinitis allergica in storage mite allergy. Allergo J Int 2022; 31: 59-68 DOI: 10.1007/s40629-022-00205-w.
  CrossrefPubMedGoogle Scholar
• 108 Höflich C, Balakirski G, Hajdu Z. et al. Management of patients with seasonal allergic rhinitis: Diagnostic consideration of sensitization to non-frequent pollen allergens. Clin Transl Allergy 2021; e12058 DOI: 10.1002/clt.12058.
  CrossrefPubMedGoogle Scholar
• 109 Ott H, Koop MV, Lange L. Kinderallergologie in Klinik und Praxis. 2. Auflage. Springer Verlag Berlin Heidelberg; 2023. DOI: 10.1007/978-3-662-62714-3_1
  CrossrefGoogle Scholar
• 110 Chaker AM. Biologics in rhinology – forthcoming personalized concepts: the future starts Ttday. Laryngorhinootologie. 2018; 97: S142-S184 DOI: 10.1055/s-0043-123484.
  Article in Thieme ConnectPubMedGoogle Scholar
• 111 Wartna JB, Bohnen AM, Elshout G, Pijnenburg MW, Pols DH, Gerth van Wijk RR, Bindels PJ. Symptomatic treatment of pollen-related allergic rhinoconjunctivitis in children: randomized controlled trial. Allergy 2017; 72: 636-644 DOI: 10.1111/all.13056.
  CrossrefPubMedGoogle Scholar
• 112 Pfaar O. et al. Guideline on allergen immunotherapy in IgE-mediated allergic diseases. Allergol Select 2022; 6: 167-232 DOI: 10.5414/ALX02331E.
  CrossrefPubMedGoogle Scholar
• 113 Stuck BA. et al. Guideline for “rhinosinusitis”-long version: S2k guideline of the German College of General Practitioners and Familiy Physicans and the German Society for Oto-Rhino-Laryngology, Head and Neck Surgery. HNO 2018; 669: 38-74 DOI: 10.1007/s00106-017-0401-5.
  CrossrefPubMedGoogle Scholar
• 114 Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie Asthma – Langfassung, 4. Auflage Version 1 2020; DOI: 10.6101/AZQ/000469.
  CrossrefPubMed
• 115 Ring J, Beyer K, Biedermann T. et al. Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update: S2k-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Medical Association of German Allergologists (AeDA), the Society of Pediatric Allergology and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DAAU), the German Professional Association of Pediatricians (BVKJ), the Society for Neonatology and Pediatric Intensive Care (GNPI), the German Society of Dermatology (DDG), the Austrian Society for Allergology and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Respiratory Society (DGP), the patient organization German Allergy and Asthma Association (DAAB), the German Working Group of Anaphylaxis Training and Education (AGATE). Allergo J Int 2021; 30: 1-25 DOI: 10.1007/s40629-020-00158-y.
  CrossrefPubMedGoogle Scholar
• 116 Greenhawt M, Sindher SB, Wang J, O’Sullivan M, du Toit G, Kim EH, Albright D, Anvari S, Arends N, Arkwright PD, Bégin P, Bluemchen K. et al. Phase 3 Trial of epicutaneous immunotherapy in toddlers with peanut allergy. N Engl J Med 2023; 388: 1755-1766 DOI: 10.1056/NEJMoa2212895.
  CrossrefPubMedGoogle Scholar
• 117 Lucendo AJ, Arias A, Tenias JM. Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a systematic review with meta-analysis. Ann Allergy Asthma Immunol 2014; 113: 624-629 DOI: 10.1016/j.anai.2014.08.004.
  CrossrefPubMedGoogle Scholar
• 118 Madisch A, Koop H. et al. Update S2k-Leitlinie Gastroösophageale Refluxkrankheit und eosinophile Ösophagitis der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) März 2023 – AWMF-Registernummer: 021 – 013. Z Gastroenterol 2023; 61: 862-933 DOI: 10.1055/a-2060-1069.
  Article in Thieme ConnectPubMedGoogle Scholar
• 119 Papapostolou G, Kiotseridis H, Romberg K, Dahl Å, Bjermer L, Lindgren M, Aronsson D, Tunsäter A, Tufvesson E. Cognitive dysfunction and quality of life during pollen season in children with seasonal allergic rhinitis. Pediatr Allergy Immunol 2021; 32: 67-76 DOI: 10.1111/pai.13328.
  CrossrefPubMedGoogle Scholar
• 120 Bensnes SS. You sneeze, you lose: The impact of pollen exposure on cognitive performance during high-stakes high school exams. J Health Econ 2016; 49: 1-13 DOI: 10.1016/j.jhealeco.2016.05.005.
  CrossrefPubMedGoogle Scholar
• 121 Jáuregui I, Mullol J, Dávila I, Ferrer M, Bartra J, Del Cuvillo A, Montoro J, Sastre J, Valero A. Allergic rhinitis and school performance. J Invest Allergol Clin Immunol 2009; 19: 32-39
  PubMedGoogle Scholar
• 122 Marshall PS, O’Hara C, Steinberg P. Effects of seasonal allergic rhinitis on selected cognitive abilities. Ann Allergy Asthma Immunol 2000; 84: 403-410 DOI: 10.1016/S1081-1206(10)62273-9.
  CrossrefPubMedGoogle Scholar
• 123 Yang CF, Yang CC, Wang IJ. Association between allergic diseases, allergic sensitization and attention-deficit/hyperactivity disorder in children: A large-scale, population-based study. J Chin Med Assoc 2018; 81: 277-283 DOI: 10.1016/j.jcma.2017.07.016.
  CrossrefPubMedGoogle Scholar
• 124 Schans JV, Çiçek R, de Vries TW, Hak E, Hoekstra PJ. Association of atopic diseases and attention-deficit/hyperactivity disorder: A systematic review and meta-analyses. Neurosci Biobehav Rev 2017; 74: 139-148 DOI: 10.1016/j.neubiorev.2017.01.011.
  CrossrefPubMedGoogle Scholar
• 125 Gao Z, Chen X, Xiang R, Zhang W, Tan L, Fan W, Liu P, Lv H, Xu Y. Changes in resting-state spontaneous brain activity in patients with allergic rhinitis: a pilot neuroimaging study. Front Neurosci 2021; 15: 697299 DOI: 10.3389/fnins.2021.697299.
  CrossrefPubMedGoogle Scholar
• 126 Fuhrmann S, Tesch F, Romanos M, Abraham S, Schmitt J. ADHD in school-age children is related to infant exposure to systemic H1-antihistamines. Allergy 2020; 75: 2956-2957 DOI: 10.1111/all.14411.
  CrossrefPubMedGoogle Scholar
• 127 Karanth TK, Karanth VKLK, Ward BK, Woodworth BA, Karanth L. Medical interventions for chronic rhinosinusitis in cystic fibrosis. Cochrane Database Syst Rev 2022; 4: CD012979 DOI: 10.1002/14651858.CD012979.pub3.
  CrossrefPubMedGoogle Scholar
• 128 Liang J, Higgins T, Ishman SL, Boss EF, Benke JR, Lin SY. Medical management of chronic rhinosinusitis in cystic fibrosis: a systematic review. Laryngoscope 2014; 124: 1308-1313 DOI: 10.1002/lary.24503.
  CrossrefPubMedGoogle Scholar
• 129 Jayawardena ADL, Fracchia MS, Bartley BL. et al. Working towards consensus in the management of pediatric chronic rhinosinusitis in cystic fibrosis. Int J Pediatr Otorhinolaryngol 2020; 135: 110047 DOI: 10.1016/j.ijporl.2020.110047.
  CrossrefPubMedGoogle Scholar
• 130 Farzal Z, Dean KM, Sreenath SB. et al. Streamlining care in cystic fibrosis: survey of otolaryngologist, pulmonologist, and patient experiences. Int Forum Allergy Rhinol 2020; 10: 591-603 DOI: 10.1002/ALR.22522.
  CrossrefPubMedGoogle Scholar
• 131 Mainz JG, Schumacher U, Schädlich K, Hentschel J, Koitschev C, Koitschev A, Riethmüller J, Prenzel F, Sommerburg O, Wiedemann B, Staab D, Gleiber W, Fischer R, Beck JF, Arnold C. Cooperators. Sino nasal inhalation of isotonic versus hypertonic saline (6.0%) in CF patients with chronic rhinosinusitis – Results of a multicenter, prospective, randomized, double-blind, controlled trial. J Cyst Fibros 2016; 15: e57-e66 DOI: 10.1016/j.jcf.2016.05.003.
  CrossrefPubMedGoogle Scholar
• 132 Mainz JG, Schien C, Schiller I, Schädlich K, Koitschev A, Koitschev C, Riethmüller J, Graepler-Mainka U, Wiedemann B, Beck JF. Sinonasal inhalation of dornase alfa administered by vibrating aerosol to cystic fibrosis patients: a double-blind placebo-controlled cross-over trial. J Cyst Fibros 2014; 13: 461-470 DOI: 10.1016/j.jcf.2014.02.005.
  CrossrefPubMedGoogle Scholar
• 133 Nährlich L, Burkhart M, Wosniok J. Deutsches Mukoviszidose-Register: Berichtsband. Bonn: Mukoviszidose e.V. Mukoviszidose Institut GmbH; 2021
  Google Scholar
• 134 Sheikh SI, Long FR, McCoy KS, Johnson T, Ryan-Wenger NA, Hayes D. Ivacaftor improves appearance of sinus disease on computerised tomography in cystic fibrosis patients with G551D mutation. Clin Otolaryngol 2015; 40: 16-21 DOI: 10.1111/coa.12310.
  CrossrefPubMedGoogle Scholar
• 135 Wucherpfennig L, Wuennemann F, Eichinger M, Seitz A, Baumann I, Stahl M, Graeber SY, Zhao S, Chung J, Schenk JP, Alrajab A, Kauczor HU, Mall MA, Sommerburg O, Wielpütz MO. Long-term effects of lumacaftor/ivacaftor on paranasal sinus abnormalities in children with cystic fibrosis detected with magnetic resonance imaging. Front Pharmacol 2023; 14: 1161891 DOI: 10.3389/fphar.2023.1161891.
  CrossrefPubMedGoogle Scholar
• 136 Wucherpfennig L, Wuennemann F, Eichinger M, Schmitt N, Seitz A, Baumann I, Stahl M, Graeber SY, Chung J, Schenk JP, Alrajab A, Kauczor HU, Mall MA, Sommerburg O, Wielpütz MO. Longitudinal Magnetic Resonance Imaging Detects Onset and Progression of Chronic Rhinosinusitis from Infancy to School Age in Cystic Fibrosis. Ann Am Thorac Soc 2023; 20: 687-697 DOI: 10.1513/AnnalsATS.202209-763OC.
  CrossrefPubMedGoogle Scholar
• 137 Stapleton AL, Kimple AJ, Goralski JL, Nouraie SM, Branstetter BF, Shaffer AD, Pilewski JM, Senior BA, Lee SE, Zemke AC. Elexacaftor-Tezacaftor- Ivacaftor improves sinonasal outcomes in cystic fibrosis. J Cyst Fibros 2022; 21: 792-799 DOI: 10.1016/j.jcf.2022.03.002.
  CrossrefPubMedGoogle Scholar
• 138 Beswick DM, Humphries SM, Balkissoon CD, Strand M, Vladar EK, Ramakrishnan VR, Taylor-Cousar JL. Olfactory dysfunction in cystic fibrosis: Impact of CFTR modulator therapy. J Cyst Fibros 2022; 21: e141-e147 DOI: 10.1016/j.jcf.2021.09.014.
  CrossrefPubMedGoogle Scholar
• 139 Wang C, Johnson R, Horani S, Brown C, Mitchell R, Shah G. Chronic rhinosinusitis and endoscopic sinus surgery in children admitted for pulmonary exacerbations of cystic fibrosis. Int J Pediatr Otorhinolaryngol 2021; 140: 110548 DOI: 10.1016/j.ijporl.2020.110548.
  CrossrefPubMedGoogle Scholar
• 140 Virgin FW, Thurm C, Sanders DB, Freeman AJ, Cogen J, Gamel B, Sawicki G, Fink AK. Prevalence, variability, and predictors of sinus surgery in pediatric patients with cystic fibrosis. Pediatr Pulmonol 2021; 56: 4029-4038 DOI: 10.1002/ppul.25669.
  CrossrefPubMedGoogle Scholar
• 141 Hughes A, Adil EA. What is the role of endoscopic sinus surgery in adult patients with cystic fibrosis. Laryngoscope 2015; 125: 2018-2020 DOI: 10.1002/lary.25210.
  CrossrefPubMedGoogle Scholar
• 142 Hughes A, Adil EA. Is Endoscopic sinus surgery beneficial post lung transplantation in cystic fibrosis patients?. Laryngoscope 2021; 131: 1446-1447 DOI: 10.1002/lary.28916.
  CrossrefPubMedGoogle Scholar
• 143 Kawai K, Dombrowski N, Sawicki GS, Adil EA. Improvement of pulmonary function in cystic fibrosis patients following endoscopic sinus surgery. Laryngoscope. 2021; 131: 1930-1938 DOI: 10.1002/lary.29409.
  CrossrefPubMedGoogle Scholar
• 144 Rampinelli V, Ferrari M, Poli P, Lancini D, Mattavelli D, Timpano S, Redaelli de Zinis LO, Badolato R, Padoan R, Berlucchi M. Paranasal mucoceles in children with cystic fibrosis: Management of a not so rare clinical condition. Am J Otolaryngol 2021; 42: 103107 DOI: 10.1016/j.amjoto.2021.103107.
  CrossrefPubMedGoogle Scholar
• 145 Helmen ZM, Little RE, Robey T. Utility of second-look endoscopy with debridement after pediatric functional endoscopic sinus surgery in patients with cystic fibrosis. Ann Otol Rhinol Laryngol 2020; 129: 1153-1162 DOI: 10.1177/0003489420922865.
  CrossrefPubMedGoogle Scholar
• 146 Maggiore G, Pietragalla M, De Amicis C, Nardi C, Bruno C, Gallo O, Bonasera L, Perrone A, Cavallo A, Colagrande S, Taccetti G, Locatello LG. The Risks of Complications During Endoscopic Sinus Surgery in Cystic Fibrosis Patients: An Anatomical and Endoscopic Study. Laryngoscope 2021; 131: E2481-E2489 DOI: 10.1002/lary.29404.
  CrossrefPubMedGoogle Scholar
• 147 Sommerburg O, Wielpütz MO, Trame JP, Wuennemann F, Opdazaite E, Stahl M, Puderbach MU, Kopp-Schneider A, Fritzsching E, Kauczor HU, Baumann I, Mall MA, Eichinger M. Magnetic Resonance Imaging Detects Chronic Rhinosinusitis in Infants and Preschool Children with Cystic Fibrosis. Ann Am Thorac Soc 2020; 17: 714-723 DOI: 10.1513/AnnalsATS.201910-777OC.
  CrossrefPubMedGoogle Scholar
• 148 Stevens DA, Moss RB, Kurup VP. et al. Allergic bronchopulmonary aspergillosis in cystic fibrosis-state of the art: Cystic Fibrosis Foundation Consensus Conference. Clin Infect Dis 2003; 37: S225-S364 DOI: 10.1086/376525.
  CrossrefPubMedGoogle Scholar
• 149 Kaplan A. Canadian guidelines for chronic rhinosinusitis: clinical summary. Can Fam Physician 2013; 59: 1275 1281
  PubMedGoogle Scholar
• 150 Kimple AJ, Senior BA, Naureckas ET. et al. Cystic fibrosis foundation otolaryngology care multidisciplinary consensus recommendations. Int Forum Allergy Rhinol 2022; 12: 1089-1103 DOI: 10.1002/alr.22974.
  CrossrefPubMedGoogle Scholar
• 151 Hackenberg S, Scherzad A. Primäre Ziliendyskinesie (PCD) – interdisziplinäre Diagnostik und Therapie. Laryngo-Rhino-OTol 2020; 99: 326-337 DOI: 10.1055/a-1074-4694.
  Article in Thieme ConnectPubMedGoogle Scholar
• 152 Kurkowiak M, Zietkiewicz E, Witt M. Recent advances in primary ciliary dyskinesia genetics. J Med Genet 2015; 52: 1-9 DOI: 10.1136/jmedgenet-2014-102755.
  CrossrefPubMedGoogle Scholar
• 153 Raidt J, Wallmeier J, Hjeij R, Onnebrink JG, Pennekamp P, Loges NT, Olbrich H, Häffner K, Dougherty GW, Omran H, Werner C. Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia. Eur Respir J 2014; 44: 1579-1588 DOI: 10.1183/09031936.00052014.
  CrossrefPubMedGoogle Scholar
• 154 Goutaki M, Shoemark A. Diagnosis of primary ciliary dyskinesia. Clin Chest Med 2022; 43: 127-140 DOI: 10.1016/j.ccm.2021.11.008.
  CrossrefPubMedGoogle Scholar
• 155 Rademacher J, Buck A, Schwerk N, Price M, Fuge J, Welte T, Ringshausen FC. Nasal Nitric Oxide Measurement and a Modified PICADAR Score for the Screening of Primary Ciliary Dyskinesia in Adults with Bronchiectasis. Pneumologie 2017; 71: 543-548 DOI: 10.1055/s-0043-111909.
  Article in Thieme ConnectPubMedGoogle Scholar
• 156 Lodes N, Seidensticker K, Perniss A, Nietzer S, Oberwinkler H, May T, Walles T, Hebestreit H, Hackenberg S, Steinke M. Investigation on ciliary functionality of different airway epithelial cell lines in three-dimensional cell culture. Tissue Eng Part A 2020; 26: 432-440 DOI: 10.1089/ten.TEA.2019.0188.
  CrossrefPubMedGoogle Scholar
• 157 Olbrich H, Cremers C, Loges NT. et al. Loss-of-function GAS8 mutations cause primary ciliary dyskinesia and disrupt the nexin-dynein regulatory complex. Am J Hum Genet 2015; 97: 546-554 DOI: 10.1016/j.ajhg.2015.08.012.
  CrossrefPubMedGoogle Scholar
• 158 Shapiro AJ, Leigh MW. Value of transmission electron microscopy for primary ciliary dyskinesia diagnosis in the era of molecular medicine: Genetic defects with normal and non-diagnostic ciliary ultrastructure. Ultrastruct Pathol 2017; 41: 373-385 DOI: 10.1080/01913123.2017.1362088.
  CrossrefPubMedGoogle Scholar
• 159 Wei S, Xie H, Cheng Y. Progress in diagnosis of primary ciliary dyskinesia. J Paediatr Child Health 2022; 58: 1736-1740 DOI: 10.1111/jpc.16196.
  CrossrefPubMedGoogle Scholar
• 160 Midilli R, Karci B, Akyildiz S. Juvenile nasopharyngeal angiofibroma: analysis of 42 cases and important aspects of endoscopic approach. Int J Pediatr Otorhinolaryngol 2009; 73: 401-408 DOI: 10.1016/j.ijporl.2008.11.005.
  CrossrefPubMedGoogle Scholar
• 161 Sikdar A, Khan S, Nivsarkar S, Phatak S. Juvenile Nasopharyngeal Angiofibroma in Adolescent Female with Subsequent ICA Canal Dehiscence: An Unknown Entity. Indian J Otolaryngol Head Neck Surg 2022; 74: 4680-4687 DOI: 10.1007/s12070-021-03008-7.
  CrossrefPubMedGoogle Scholar
• 162 Lund VJ, Stammberger H, Nicolai P. et al. European position paper on endoscopic management of tumours of the nose, paranasal sinuses and skull base. Rhinol Suppl 2010; 22: 1-143
  PubMedGoogle Scholar
• 163 Li W, Ni Y, Lu H, Hu L, Wang D. Current perspectives on the origin theory of juvenile nasopharyngeal angiofibroma. Discov Med 2019; 27: 245-254
  PubMedGoogle Scholar
• 164 Hwang HC, Mills SE, Patterson K, Gown AM. Expression of androgen receptors in nasopharyngeal angiofibroma: an immunohistochemical study of 24 cases. Mod Pathol 1998; 11: 1122-1126
  PubMedGoogle Scholar
• 165 Klockars T, Renkonen S, Leivo I, Hagstrom J, Makitie AA. Juvenile nasopharyngeal angiofibroma: no evidence for inheritance or association with familial adenomatous polyposis. Fam Cancer 2010; 9: 401-403 DOI: 10.1007/s10689-010-9331-z.
  CrossrefPubMedGoogle Scholar
• 166 Kumagami H. Estradiol, dihydrotestosterone, and testosterone in juvenile nasopharyngeal angiofibroma tissue. Am J Rhinol 1993; 7: 101-104
  CrossrefPubMedGoogle Scholar
• 167 Doody J, Adil EA, Trenor CC, Cunningham MJ. The Genetic and Molecular Determinants of Juvenile Nasopharyngeal Angiofibroma: A Systematic Review. Ann Otol Rhinol Laryngol 2019; 128: 1061-1072 DOI: 10.1177/0003489419850194.
  CrossrefPubMedGoogle Scholar
• 168 Schlauder SM, Knapp C, Steffensen TS, Bui MM. Aromatase may play a critical role in the pathogenesis of juvenile nasopharyngeal angiofibroma. Fetal Pediatr Pathol 2009; 28: 232-238 DOI: 10.3109/15513810903073724.
  CrossrefPubMedGoogle Scholar
• 169 Sitenga G, Granger P, Hepola K, Aird J, Silberstein PT. The use of flutamide for the neoadjuvant treatment of juvenile nasopharyngeal angiofibroma: a review of the literature comparing results by pubertal status and tumor stage. Int J Dermatol 2022; 61: 1346-1352 DOI: 10.1111/ijd.15966.
  CrossrefPubMedGoogle Scholar
• 170 Diaz A, Wang E, Bujnowski D, Arimoto R, Armstrong M, Cyberski T, Nordgren R, Seal SM, Kass-Hout T, Roxbury C. Embolization in juvenile nasopharyngeal angiofibroma: a systematic review and meta-analysis. Laryngosckope 2023; DOI: 10.1002/lary.30616.
  CrossrefPubMedGoogle Scholar
• 171 Manogaran RS, Mathialagan A, Singh V, Mishra P, Jain R, Keshri A. Role of transarterial angiography with embolization in deciding surgical approach to juvenile nasopharyngeal angiofibroma: a step-ladder approach. J Neurol Surg B Skull Base 2021; 82: 547-555 DOI: 10.1055/s-0040-1715594.
  Article in Thieme ConnectPubMedGoogle Scholar
• 172 Cohen-Cohen S, Scheitler KM, Choby G, Janus J, Moore EJ, Kasperbauer JL, Cloft HJ, Link M, Van Gompel JJ. Contemporary surgical management of juvenile nasopharyngeal angiofibroma. J Neurol Surg B Skull Base 2021; 83: e266-e273 DOI: 10.1055/s-0041-1725031.
  Article in Thieme ConnectPubMedGoogle Scholar