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Synthesis 2023; 55(20): 3289-3296
DOI: 10.1055/a-2093-3333
paper

Palladium-Catalyzed Synthesis of Benzofuran Spiroketals Derived from Cholesterol; NMR and X-ray Characterization

William H. García-Santos
,
Ariadna M. Quiroz-Mendoza
,
Martha C. Mayorquín-Torres
,
Marcos Flores-Álamo
,
Martin A. Iglesias-Arteaga  ∗
The authors acknowledge the financial support provided by Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México (Grant IN204323), Consejo Nacional de Ciencia y Tecnología (CONACyT, Grant A1-S-8019) and the Faculty of Chemistry, Universidad Nacional Autónoma de México (PAIP-5000-9063). W.H.G.-S. thanks Dirección General de Asuntos del Personal Académico for the Postdoctoral Fellowship granted.
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Abstract

The synthesis of two diastereomeric steroid spiroketals bearing a 2,3-dihydrobenzofuran moiety is described. The structure of the obtained compounds was elucidated by combined 1D and 2D NMR techniques and corroborated by X-ray crystallography studies.

Key words

steroids - benzofuran spiroketals - palladium-catalyzed spiroketalization - NMR - X-ray diffraction

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-2093-3333.
  • Supporting Information


Publication History

Received: 03 April 2023

Accepted after revision: 15 May 2023

Accepted Manuscript online:
15 May 2023

Article published online:
14 June 2023

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