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Planta Med 2007; 73(12): 1284-1286
DOI: 10.1055/s-2007-990218
Pharmacology
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Biflavones of Decussocarpus rospigliosii as Phosphodiesterases Inhibitors

Mehdi Chaabi1 , 2 , Cyril Antheaume1 , Bernard Weniger1 , 2 , Hélène Justiniano1 , 3 , Claire Lugnier1 , 3 , Annelise Lobstein1 , 2
  • 1LC1 UMR-CNRS 7175 ‘Biotechnologies, Biomolécules et Innovations Thérapeutiques’, Faculté de Pharmacie de Strasbourg, Illkirch, France
  • 2Equipe Pharmacognosie et Molécules Naturelles Bioactives, Faculté de Pharmacie de Strasbourg, Illkirch, France
  • 3Equipe Pharmacologie et Physicochimie des Interactions Moléculaires et Cellulaires, Faculté de Pharmacie de Strasbourg, Illkirch, France
Further Information

Publication History

Received: June 14, 2007 Revised: July 20, 2007

Accepted: July 23, 2007

Publication Date:
24 September 2007 (online)

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Abstract

A phytochemical study of an ethyl acetate extract of Decussocarpus rospigliosii leaves led to the isolation of six 3′-8′′-biapigenin derivatives identified as amentoflavone (1), podocarpusflavone A (2), sequoiaflavone (3), podocarpusflavone B (4), 7,7′′-di-O-methylamentoflavone (5) and heveaflavone (6). Biflavones 1 - 4 showed strong inhibitory activity on several PDE isoforms. Biflavone (5) showed selective and potent inhibition of the PDE4 isoform (IC50 = 1.48 ± 0.21 μM) and was almost as active as the reference drug Rolipram (IC50 = 1.1 ± 0.2 μM).

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Dr. Annelise Lobstein

LC1/UMR-CNRS 7175

Pharmacognosie et Molécules Naturelles Bioactives

Faculté de Pharmacie

Université Louis Pasteur - Strasbourg I

74 route du Rhin

BP60024

67401 Illkirch Cedex

France

Phone: +33-3-9024-42 39

Fax: +33-3-9024-4311

Email: annelise.lobstein@pharma.u-strasbg.fr

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