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Horm Metab Res 1990; 22(6): 352-355
DOI: 10.1055/s-2007-1004918
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Urinary Excretion of Digoxin-Like Factor (DLF) and ADH during DOCA-Salt and Goldblatt 2 Kidney-1 Clip Hypertension Development

F. Vargas, I. Casanova, J. M. Haro, J. D. Luna1
  • Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Granada, Spain
  • 1Department of Biostatistics, Faculty of Medicine, University of Granada, Granada, Spain
Further Information

Publication History

1987

1989

Publication Date:
14 March 2008 (online)

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Summary

Urinary digoxin-like factor, ADH, sodium and potassium excretion and urine osmolality were studied during the development of two pathogenically different models of hypertension, DOCA-salt (low-renin) and Goldblatt 2 kidney-1 clip (renin-dependent). Urinary digoxin-like factor was increased in rats that were given saline (NaCl 1%) to drink, uninephrectomized-salt and DOCA-salt rats, with no significant differences between the two groups, urinary ADH was elevated in DOCA-salt rats during the study, compared with uninephrectomized-salt rats. Urinary digoxin-like factor and urinary ADH were not significantly modified in Goldblatt 2 kidney-1 clip and sham-operated rats. In addition, positive correlations between digoxin-like factor urinary excretion and urinary ADH and also with sodium urinary excretion were found. These data suggest that: a) digoxin-like factor and ADH could play a role in the pathogenesis of DOCA-salt but not in Goldblatt 2 kidney-1 clip hypertension. b) A common mechanism may stimulate ADH and digoxin-like factor simultaneously. c) Digoxin-like factor plays a role in the control of urinary sodium excretion.

Key words

Urinary Excretion - Digoxin-Like Factor - ADH - Experimental Hypertension - Urine Osmolality

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