Anti-Allergic Effect of Bryonolic Acid from Luffa cylindrica Cell Suspension Cultures

Shigeo Tanaka; Chikari Uno; Makoto Akimoto; Mamoru Tabata; Chie Honda; Wasuke Kamisako

doi:10.1055/s-2006-960199

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Planta Med 1991; 57(6): 527-530
DOI: 10.1055/s-2006-960199

Papers

Anti-Allergic Effect of Bryonolic Acid from Luffa cylindrica Cell Suspension Cultures

Shigeo Tanaka¹ , Chikari Uno¹ , Makoto Akimoto¹ , Mamoru Tabata¹ , Chie Honda² , Wasuke Kamisako²

¹Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Kyoto, 606 Japan
²Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Koshien, Nishinomiya, 663 Japan

Further Information

Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

The anti-allergic activity of bryonolic acid (1) isolated from the cultured cells of Luffa cylindrica L. (Cucurbitaceae) was compared with that of glycyrrhetinic acid (2), the aglycone of gylcyrrhizin from licorice. Compound 1, when administered to rats intraperitoneally at a dose of 600 mg/kg, inhibited homologous passive cutaneous anaphylaxis more strongly than 2 at the same dose. Compound 1 also significantly inhibited delayed hypersensitivity in mice which could not be inhibited by 2. In contrast to 2, 1 showed not only little toxicity but no visible side effects on mice, without impairing the activity of the hepatic enzyme (4,5β-dihydrocortisone:NADP⁺ Δ⁴-oxidoreductase) involved in steroid catabolism.

Key words

Anti-allergic activity - bryonolic acid - 3β-hydroxy-D:C-friedoolean-8-en-29-oic acid - glycyrrhetinic acid - Luffa cylindrica - cell suspension culture

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