Ginsenoside Rh4, A Genuine Dammarane Glycoside from Korean Red Ginseng

Nam-In Baek; Dong Seon Kim; You Hui Lee; Jong Dae Park; Chun Bae Lee; Shin Il Kim

doi:10.1055/s-2006-957816

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Planta Med 1996; 62(1): 86-87
DOI: 10.1055/s-2006-957816

Letter

Ginsenoside Rh₄, A Genuine Dammarane Glycoside from Korean Red Ginseng

Nam-In Baek¹ , Dong Seon Kim² , You Hui Lee¹ , Jong Dae Park¹ , Chun Bae Lee² , Shin Il Kim¹

¹Korea Ginseng & Tobacco Research Institute, Yuseong P.O. Box 7, Taejeon, 305-345 Korea
²Department of Biochemistry, Chungnam National University, Kungdong 220, Yuseong, Taejeon, 305-764 Korea

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Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

A genuine glycoside, named ginsenoside Rh₄, was isolated from Korean red ginseng (Panax ginseng C. A. Meyer) through repeated column chromatography, and its chemical structure was established to be 6-O-β-D-glucopyranosyldammar-20(22),24-diene-3β,6α,12β-triol by spectral and chemical methods. The stereochemistry of a double bond at C-20(22) of ginsenoside Rh₄ was characterized as (E) from a NOESY experiment in the ¹H-NMR of the aglycone. Cytotoxic activities of ginsenoside Rh₄ and its aglycone against cancer cell lines were evaluated by use of the SRB method.

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