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Planta Med 2006; 72(9): 801-806
DOI: 10.1055/s-2006-941545
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Involvement of Nuclear Factor-κB in the Inhibition of Pro-Inflammatory Mediators by Pinosylvin

Jongsung Lee1 , 2 , Eunsun Jung1 , Jihee Lim1 , 3 , Jiyoung Lee1 , Sungran Hur1 , Sang Suk Kim1 , Sangbin Lim3 , Chang-Gu Hyun1 , Yeong Shik Kim2 , Deokhoon Park1
  • 1Biospectrum Life Science Institute, Gunpo City, Gyunggi Do, Republic of Korea
  • 2Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea
  • 3Department of Food Science and Nutrition, College of Natural Sciences, Cheju National University, Cheju Do, Republic of Korea
Further Information

Publication History

Received: January 27, 2006

Accepted: April 25, 2006

Publication Date:
19 June 2006 (online)

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Abstract

Nuclear factor-κB (NF-κB) is a critical transcription factor for maximal expression of many of the cytokines that are involved in the pathogenesis of inflammatory diseases. In this study, we found that pinosylvin, a natural stilbenoid that is a component of the pine leaf (Pinus densiflora), significantly inhibited LPS-induced NF-κB activation in a concentration-dependent manner. Additionally, pinosylvin was found to inhibit the LPS-induced phosphorylation and degradation of IκB α in THP-1 cells. Therefore, we have attempted to determine whether pinosylvin can inhibit the expression of cytokines possessing NF-κB binding sites in their promoter regions. In a consistent result, pinosylvin inhibited LPS-induced production of TNF α and interleukin-8 (IL-8). Taken together, these results show that pinosylvin suppresses the production of pro-inflammatory mediators through the inhibition of the NF-κB signaling pathway.

Abbreviations

LPS:Lipopolysaccharide

NF-κB:Nuclear factor-κB

COX-2:Cyclooxygenase-2

Key words

Pinosylvin - nuclear factor-κB - interleukin-8 - IκB α

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Dr. Deokhoon Park

Biospectrum Life Science Institute

SK Ventium 101-701

Dangjung Dong

Gunpo City

436-776 Gyunggi Do

Republic of Korea

Phone: +82-31-436-2090

Fax: +82-31-436-0605

Email: pdh@biospectrum.com

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