Download PDF
Horm Metab Res 1980; 12(4): 158-164
DOI: 10.1055/s-2007-996230
© Georg Thieme Verlag, Stuttgart · New York

Somatomedin Activity in Sera of Genetically Small Mice

S. P. Nissley1 , R. A. Knazek2 , G. L. Wolff3
  • 1Endocrine Section, National Cancer Institute, National Institues of Health, Bethesda, Maryland, USA
  • 2Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
  • 3Food and Drug administration, National Center for Toxicological Research, Jefferson, Arkansas, USA
Further Information

Publication History

1979

1979

Publication Date:
22 April 2008 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

Somatomedin activity as determined by the stimulation of [3H]thymidine incorporation into chick embryo fibroblast DNA, was measured in extracts of sera from genetically small mice. Somatomedin activity was low in the sera from growth hormone deficient mice [Snell (dw/dw), Ames (df/df), and little (lit/lit)] whereas Somatomedin activity was normal in serum from the pygmy (pg/pg) mouse, a mutant proposed as a model for growth hormone resistance. GH treatment of the Snell mouse resulted in an increase in somatomedin activity to normal levels.

Key-words

Snell (dw/dw), Ames (df/df), little (lit/lit), pygmy (pg/pg) somatomedin activity - chick embryo fibroblasts - growth hormone

      >