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Horm Metab Res 1984; 16(9): 483-486
DOI: 10.1055/s-2007-1014825
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Biochemical Determination of Training Effects Using Insulin Clamp Technique

Y. Sato, A. Iguchi, N. Sakamoto
  • Third Department of Internal Medicine, School of Medicine Nagoya University, Nagoya, Japan
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Publication History

1983

1983

Publication Date:
14 March 2008 (online)

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Summary

Tissue sensitivity to insulin was evaluated in 6 trained athletes and 9 untrained controls using the euglycemic insulin clamp technique. The amount of glucose metabolism is a measure of overall tissue sensitivity to insulin. During insulin clamp study comparable plasma glucose (80-90 mg/dl) and insulin (90-100 μU/ml) were achieved in both groups. The glucose infusion rate in the athletes (10.70 ± 0.32 mg/kg/min) was significantly higher than in the controls (7.37 ± 0.23 mg/kg/min). During euglycemic hyperinsulinemia plasma FFA decreased by 80% while glycerol showed only a 20% reduction in both groups. Urinary catecholamine concentrations in the athletes were similar to those in the controls, and these levels did not change during the insulin clamp peiod.

From these results, it might be concluded that tissue sensitivity to exogenous insulin is 45% higher in trained athletes and that physical exercise can reduce the insulin requirements in insulin-dependent diabetic patients in additions to being beneficial to noninsulin-dependent diabetics.

Key-Words:

Insulin Clamp Technique - Training Effects - Athletes - Diabetes

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