Inhibitory Effects of Plant Secondary Metabolites on Cytotoxic Activity of Polymorphonuclear Leucocytes

Kaoru Kinoshita; Kaoru Morikawa; Masahiko Fujita; Shinsaku Natori

doi:10.1055/s-2006-961415

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Planta Med 1992; 58(2): 137-145
DOI: 10.1055/s-2006-961415

Papers

Inhibitory Effects of Plant Secondary Metabolites on Cytotoxic Activity of Polymorphonuclear Leucocytes

Kaoru Kinoshita¹ , Kaoru Morikawa² , Masahiko Fujita² , Shinsaku Natori¹

¹Meiji College of Pharmacy, Yato-cho, Tanashi-shi, Tokyo 188, Japan
²National Institute of Public Health, Shirokanedai-4-chome, Minato-ku, Tokyo 108, Japan

Further Information

Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

The inhibitory effects of 151 natural products, representing most of the frequently occurring types, on the cytotoxicity to MM2 tumor cells of polymorphonuclear leucocytes (PMN) induced by TAK, a polysaccharide immunomodulator, were examined. Forty-two compounds inhibited the TAK-induced activation of PMN. Among them, some naturally occurring quinones and various alkaloids (nicotine, Cinchona alkaloids, isoquinoline alkaloids such as cepharanthine, and indole alkaloids such as ajmaline) exhibited potent inhibitory effects. Using the inhibition assay for monitoring, the extracts of Hydrangea Dulcis folium, Scopoliae rhizoma, Cinchona cortex, Magnoliae cortex, Stephania tuber, and Rauwolfia radix were analysed to characterize the active constituents.

Key words

Cytotoxicity - inhibition of TAK-induced activation - polymorphonuclear leucocytes - secondary metabolites - quinones - isoquinoline alkaloids - indole alkaloids

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