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Planta Med 2005; 71(8): 787-789
DOI: 10.1055/s-2005-871253
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Inhibition of Thrombin Activity by Selected Natural Products in Comparison to Neutrophil Elastase

Matthias F. Melzig1 , Kristin Henke1
  • 1Institut für Pharmazie, Freie Universität Berlin, Berlin, Germany
Further Information

Publication History

Received: February 15, 2005

Accepted: April 13, 2005

Publication Date:
08 August 2005 (online)

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Abstract

Enzymatic thrombin activity is significantly inhibited only by a few selected natural phenolic compounds (myricetin, rosmarinic acid, caffeic acid phenethyl ester) but more strongly by unsaturated fatty acids like erucic acid and oleic acids. Compared to the inhibitory potential against neutrophil elastase, thrombin activity is rather weakly inhibited by phenolic compounds and fatty acids. Because of the importance of thrombin as a ligand for protease-activated receptor 1 (PAR-1), which is involved in inflammation, the inhibition of thrombin activity by natural compounds might enhance the anti-inflammatory effects of neutrophil elastase inhibition.

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Prof. Dr. M. F. Melzig

Institut für Pharmazie

Freie Universität Berlin

Königin-Luise-Str 2 +4

14195 Berlin

Germany

Phone: +49-30-838-51451

Fax: +49-30-838-51461

Email: melzig@zedat.fu-berlin.de

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