Recent Findings Shed Light on the Aetiopathogenesis of Sjögren’s Syndrome

 

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Zusammenfassung

Das systemische klinische Bild der Patienten mit SS kann auf eine Disposition vieler Zellarten zurückgeführt werden, bei einer Konfrontation mit Stressreizen überzureagieren. Dies beeinflusst die elementaren zellulären Vorgänge wie Apoptose und Acethylcholine-Rezeptor-Signalvermittlung. Diese Hyperreaktivität des Gewebes kann auch die beobachteten autoimmunogenen Eigenschaften erklären und könnte eine ätiopathogenetische Determinante beim SS darstellen.

Abstract

The systemic clinical picture of SS patients can be traced back to a disposition of many cell types to over-react when confronted with stress stimuli. This will influence basic cellular processes such as apoptosis and acetylcholine receptor signaling. This tissue hyper-reactivity may also explain the observed autoimmune features, and may constitute a major aetiopathogenetic determinant in SS.

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Anders Bredberg, M.D., Ph. D.

Sjögren’s Syndrome Research Centre, Department of Medical Microbiology, University Hospital

20502 Malmö

Sweden

Email: anders.bredberg@mikrobiol.mas.lu.se