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Synthesis
DOI: 10.1055/s-0042-1751463
DOI: 10.1055/s-0042-1751463
paper
Special Issue New Trends in Organic Synthesis from Chinese Chemists
Boryl Radical-Promoted Deoxygenative Alkylation of Benzyl Acetates
We thank the National Natural Science Foundation of China (21971226, 22171253), Natural Science Foundation of Anhui Province (2108085MB59), and the Fundamental Research Funds for the Central Universities (WK2060000017) for financial support of this research.
Abstract
Deoxygenative alkylation of benzyl alcohols was realized by using acetate as the alcohol activation group. The C–O bond homolysis is achieved by a boryl radical-promoted β-scission process. The strategy is amenable to a variety of benzyl alcohols, including primary, secondary, and more challenging tertiary alcohols. The synthetic practicability was demonstrated by a gram-scale one-pot reaction.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0042-1751463.
- Supporting Information
Publication History
Received: 23 March 2023
Accepted after revision: 12 May 2023
Article published online:
27 June 2023
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