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Thromb Haemost 1970; 24(03/04): 419-431
DOI: 10.1055/s-0038-1654251
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Platelet Aggregation by a Specific Human Immunoglobulin Preparation

G de Gaetano M. D.
1   Laboratory of Blood Coagulation, Academisch Ziekenhuis St. Rafaël, Leuven, Belgium
,
J Vermylen M. D.
1   Laboratory of Blood Coagulation, Academisch Ziekenhuis St. Rafaël, Leuven, Belgium
,
M Verstraete M. D.
1   Laboratory of Blood Coagulation, Academisch Ziekenhuis St. Rafaël, Leuven, Belgium
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Publication History

Publication Date:
28 June 2018 (online)

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Summary

A patient with severe chronic thrombocytopenic purpura is described, whose serum, after repeated transfusions of platelet-rich plasma, of her ABO blood group, was found to contain immunoglobulin G, which produced clumping in platelet-rich plasma from 15 volunteers out of 20. Direct and indirect evidence was obtained that clumping was due to release of endogenous platelet-ADP. In addition, a direct effect of the immunoglobulin preparation on the platelet membrane could be demonstrated.

 

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