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Exp Clin Endocrinol Diabetes 2015; 123(05): 267-271
DOI: 10.1055/s-0035-1547257
Article
© Georg Thieme Verlag KG Stuttgart · New York

Nephropathy, but not Angiographically Proven Retinopathy, is Associated with Neutrophil to Lymphocyte Ratio in Patients with Type 2 Diabetes

H. Ciray
1   Department of Internal Medicine, Karaman State Hospital, Karaman, Turkey
,
A. H. Aksoy
2   Department of Ophthalmology, Karaman, State Hospital, Karaman, Turkey
,
N. Ulu
3   Secretary General, Turkish Public Hospitals Institution, Karaman Association of Public Hospitals, Karaman, Turkey
,
A. Cizmecioglu
1   Department of Internal Medicine, Karaman State Hospital, Karaman, Turkey
,
A. Gaipov
4   Extracorporeal Hemocorrection Unit, National Scientific Medical Research Center, Astana, Kazakhstan
,
Y. Solak
5   Nephrology Unit, Department of Internal Medicine, Karaman State Hospital, Karaman, Turkey
› Author Affiliations
Further Information

Publication History

received 02 September 2014
first decision 16 February 2015

accepted 18 February 2015

Publication Date:
08 April 2015 (online)

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Abstract

Background: Type 2 Diabetes Mellitus is a leading cause of end stage renal disease in the worldwide. Inflammation is regarded as one of the main reasons for the progression of diabetes complications. We aimed to evaluate the association of neutrophil to lymphocyte ratio (NLR) as indicator of systemic inflammation with diabetic retinopathy and nephropathy.

Patients and Methods: This is a cross-sectional study of 114 prevalent type 2 diabetic subjects. All of the patients underwent detailed examination for the presence of diabetic retinopathy and nephropathy. Diabetic retinopathy was approved and classified according to findings based on flouresceint fundal angiography results. Estimated glomerular filtration rate (eGFR) and microalbumin to creatinine ratio were calculated to establish the diabetic nephropathy. NLR was calculated as ratio of absolute neutrophil count to absolute lymphocyte count.

Results: Retinopathy was present in 55 (48.2%) out of 114 patients, whereas nephropathy was present in 62 patients (54.3%). NLR was significantly higher in patients with nephropathy than in patients without nephropathy. NLR was also positively correlated with CRP (p=0.017, r=0.224) and microalbuminuria (p=0.016, r=0.257) whereas negatively correlated with eGFR (p<0.001, r=−0.337) values in the whole cohort. NLR was independent predictors for diabetic nephropathy, whereas it did not appear as an independent associate of diabetic retinopathy.

Conclusion: NLR and diabetic nephropathy have an independent association between them whereas there was no independent association between NLR with retinopathy in type 2 diabetic patients.

Key words

neutrophil to lymphocyte ratio - diabetic nephropathy - diabetic retinopathy - inflammation - type 2 diabetes mellitus
 

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