Synthesis 2014; 46(23): 3172-3179
DOI: 10.1055/s-0034-1379327
feature article
© Georg Thieme Verlag Stuttgart · New York

Three-Component Reaction between Isocyanides, Aliphatic Amines and Elemental Sulfur: Preparation of Thioureas under Mild Conditions with Complete­ Atom Economy

Thanh Binh Nguyen*
Centre de Recherche de Gif-sur-Yvette, Institut de Chimie des Substances Naturelles, CNRS, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France   Fax: +33(1)69077247   Email: nguyen@icsn.cnrs-gif.fr   Email: ali.almourabit@cnrs.fr
,
Ludmila Ermolenko
Centre de Recherche de Gif-sur-Yvette, Institut de Chimie des Substances Naturelles, CNRS, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France   Fax: +33(1)69077247   Email: nguyen@icsn.cnrs-gif.fr   Email: ali.almourabit@cnrs.fr
,
Ali Al-Mourabit*
Centre de Recherche de Gif-sur-Yvette, Institut de Chimie des Substances Naturelles, CNRS, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France   Fax: +33(1)69077247   Email: nguyen@icsn.cnrs-gif.fr   Email: ali.almourabit@cnrs.fr
› Author Affiliations
Further Information

Publication History

Received: 05 August 2014

Accepted after revision: 26 September 2014

Publication Date:
31 October 2014 (online)


Abstract

The reaction of isocyanides with aliphatic amines in the presence of elemental sulfur was found to proceed efficiently at, or near, room temperature to produce thioureas in excellent yields and with complete atom economy.

Supporting Information

 
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