Cytotoxic ent-Kaurane Diterpenoids from Isodon henryi

 

 Buy Article Permissions and Reprints

Abstract

Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ent-kaurane diterpenoids, named minheryins A-G (1 – 7), together with the six known ent-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7 – 13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC₅₀ values <0.50 μg/mL. Isolates 1 – 5 were evaluated against the K562 cell line, and only 3 showed weak activity.

References

• 1 Sun H D, Xu Y L, Jiang B. Diterpenoids from Isodon species, 1st edition. Beijing; Science Press 2001: 93
  Google Scholar
• 2 Academia Sinica. Botany of China, Vol. 66. Beijing; Science Publishing House 1979: 510
  Google Scholar
• 3 Zhang J D, Long W C, Zhu Y H. 50 Examples of treatment of acute infant enteritis using ”Ku ShaYao”.  J Hunan Med. 1983;  3 64
  PubMedGoogle Scholar
• 4 Li B L, Pan Y J, Yu K B. Taibaihenryiin C, a diterpenoid with a novel skeleton from Isodon henryi. .  Tetrahedron Lett. 2002;  43 3845-7
  CrossrefPubMedGoogle Scholar
• 5 Wang Z Q, Wang X R, Dong J G, Xue Z W, Wang X W. Chemical structure of henryi A.  Acta Bot Sin. 1984;  26 634-8
  PubMedGoogle Scholar
• 6 Meng X J, Chen Y Z, Cui Y X, Cheng J L. Diterpenoids from Rabdosia henryi. .  J Nat Prod. 1988;  51 812-6
  CrossrefPubMedGoogle Scholar
• 7 Li J C, Liu C J, An X Z, Sun H D, Lin Z W. The structure of henryi.  Acta Bot Yunnan. 1984;  6 453-6
  PubMedGoogle Scholar
• 8 Xu Y L, Sun X C, Sun H D, Lin Z W, Wang D Z. Chemical structures of glaucocalyxin A and B.  Acta Bot Yunnan. 1981;  3 283-6
  PubMedGoogle Scholar
• 9 Ding L, Wang H, Liu G A, Yang D J. A new ent-kaurane deterpenoid from Isodon excisoides. .  J Chem Reson. 2004;  10 697-8
  PubMedGoogle Scholar
• 10 Takeda Y, Fujita T, Ueno A. Structures of leukamenins.  Chem Lett. 1981;  1229-32
  CrossrefPubMedGoogle Scholar
• 11 Wang X R, Wang Z Q, Shi P C, Zhou B N. Wangzaozin A from Isodon amethystoides. .  Zhong Cao Yao. 1982;  13 12-13
  PubMedGoogle Scholar
• 12 Li Y Z, Chen Y Z. Diterpenoids from Rabdosia pseudo-irrorata. .  J Nat Prod. 1990;  53 841-4
  CrossrefPubMedGoogle Scholar
• 13 Ding L, Liu G A, Wang L, Sun K, Wang H. Ind. Cytotoxic ent-kaurane diterpenoids from Isodon racemosa. .  Indian J Chem B. 2006;  45 548-51
  PubMedGoogle Scholar
• 14 Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D. et al . Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.  J Natl Cancer Inst. 1991;  83 757-66
  CrossrefPubMedGoogle Scholar
• 15 Li Y Z, Chen Y Z. Diterpenoids from Rabdosia pseudo-irrorata. .  Phytochemistry. 1991;  30 283-5
  CrossrefPubMedGoogle Scholar
• 16 Kubo I, Taniguchi Y, Satomura Y, Kubota T. Antibacterial activity and chemical structure of diterpenoids.  Agric Biol Chem. 1974;  38 1261-2
  PubMedGoogle Scholar

Prof. Han-Dong Sun

State Key Laboratory of Phytochemistry and Plant Resources in West China

Kunming Institute of Botany

Chinese Academy of Sciences

Lanhei Road 132

Kunming 650204

People's Republic of China

Phone: +86-871-522-3251

Fax: +86-871-521-6343

Email: hdsun@mail.kib.ac.cn