Advanced Morphological and Biochemical Magnetic Resonance Imaging of Cartilage Repair Procedures in the Knee Joint at 3 Tesla

 

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ABSTRACT

Morphological and biochemical magnetic resonance imaging (MRI) is due to high field MR systems, advanced coil technology, and sophisticated sequence protocols capable of visualizing articular cartilage in vivo with high resolution in clinical applicable scan time. Several conventional two-dimensional (2D) and three-dimensional (3D) approaches show changes in cartilage structure. Furthermore newer isotropic 3D sequences show great promise in improving cartilage imaging and additionally in diagnosing surrounding pathologies within the knee joint. Functional MR approaches are additionally able to provide a specific measure of the composition of cartilage. Cartilage physiology and ultra-structure can be determined, changes in cartilage macromolecules can be detected, and cartilage repair tissue can thus be assessed and potentially differentiated. In cartilage defects and following nonsurgical and surgical cartilage repair, morphological MRI provides the basis for diagnosis and follow-up evaluation, whereas biochemical MRI provides a deeper insight into the composition of cartilage and cartilage repair tissue. A combination of both, together with clinical evaluation, may represent a desirable multimodal approach in the future, also available in routine clinical use.

REFERENCES

• 1 Widuchowski W, Widuchowski J, Trzaska T. Articular cartilage defects: study of 25,124 knee arthroscopies.  Knee. 2007;  14(3) 177-182
  CrossrefPubMedGoogle Scholar
• 2 Ding C, Garnero P, Cicuttini F et al.. Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown.  Osteoarthritis Cartilage. 2005;  13(3) 198-205
  CrossrefPubMedGoogle Scholar
• 3 Peyron J G. Epidemiological aspects of osteoarthritis.  Scand J Rheumatol Suppl. 1988;  77 29-33
  PubMedGoogle Scholar
• 4 Reginster J Y. The prevalence and burden of arthritis.  Rheumatology (Oxford). 2002;  41(Supp 1) 3-6
  CrossrefPubMedGoogle Scholar
• 5 Zhang W, Doherty M. EULAR recommendations for knee and hip osteoarthritis: a critique of the methodology.  Br J Sports Med. 2006;  40(8) 664-669
  CrossrefPubMedGoogle Scholar
• 6 Bartlett W, Skinner J A, Gooding C R et al.. Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study.  J Bone Joint Surg Br. 2005;  87(5) 640-645
  PubMedGoogle Scholar
• 7 Behrens P, Bitter T, Kurz B, Russlies M. Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI)—5-year follow-up.  Knee. 2006;  13(3) 194-202
  CrossrefPubMedGoogle Scholar
• 8 Gudas R, Kalesinskas R J, Kimtys V et al.. A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes.  Arthroscopy. 2005;  21(9) 1066-1075
  Google Scholar
• 9 Gudas R, Stankevicius E, Monastyreckiene E, Pranys D, Kalesinskas R J. Osteochondral autologous transplantation versus microfracture for the treatment of articular cartilage defects in the knee joint in athletes.  Knee Surg Sports Traumatol Arthrosc. 2006;  14(9) 834-842
  CrossrefPubMedGoogle Scholar
• 10 Knutsen G, Drogset J O, Engebretsen L et al.. A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years.  J Bone Joint Surg Am. 2007;  89(10) 2105-2112
  CrossrefPubMedGoogle Scholar
• 11 Knutsen G, Engebretsen L, Ludvigsen T C et al.. Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial.  J Bone Joint Surg Am. 2004;  86-A(3) 455-464
  PubMedGoogle Scholar
• 12 Eckstein F, Ateshian G, Burgkart R et al.. Proposal for a nomenclature for magnetic resonance imaging based measures of articular cartilage in osteoarthritis.  Osteoarthritis Cartilage. 2006;  14(10) 974-983
  CrossrefPubMedGoogle Scholar
• 13 Gold G E, Burstein D, Dardzinski B et al.. MRI of articular cartilage in OA: novel pulse sequences and compositional/functional markers.  Osteoarthritis Cartilage. 2006;  14 Suppl A A76-86
  PubMedGoogle Scholar
• 14 Recht M, White L M, Winalski C S et al.. MR imaging of cartilage repair procedures.  Skeletal Radiol. 2003;  32(4) 185-200
  CrossrefPubMedGoogle Scholar
• 15 Recht M P, Goodwin D W, Winalski C S, White L M. MRI of articular cartilage: revisiting current status and future directions.  AJR Am J Roentgenol. 2005;  185(4) 899-914
  CrossrefPubMedGoogle Scholar
• 16 Trattnig S, Millington S A, Szomolanyi P, Marlovits S. MR imaging of osteochondral grafts and autologous chondrocyte implantation.  Eur Radiol. 2007;  17(1) 103-118
  CrossrefPubMedGoogle Scholar
• 17 Van Breuseghem I. Ultrastructural MR imaging techniques of the knee articular cartilage: problems for routine clinical application.  Eur Radiol. 2004;  14(2) 184-192
  CrossrefPubMedGoogle Scholar
• 18 Mamisch T C, Menzel M I, Welsch G H et al.. Steady-state diffusion imaging for MR in-vivo evaluation of reparative cartilage after matrix-associated autologous chondrocyte transplantation at 3 Tesla—preliminary results.  Eur J Radiol. 2008;  65(1) 72-79
  CrossrefPubMedGoogle Scholar
• 19 Trattnig S, Mamisch T C, Pinker K et al.. Differentiating normal hyaline cartilage from post-surgical repair tissue using fast gradient echo imaging in delayed gadolinium-enhanced MRI (dGEMRIC) at 3 Tesla.  Eur Radiol. 2008;  18 1251-1259
  CrossrefPubMedGoogle Scholar
• 20 Trattnig S, Mamisch T C, Welsch G H et al.. Quantitative T2 mapping of matrix-associated autologous chondrocyte transplantation at 3 Tesla: an in vivo cross-sectional study.  Invest Radiol. 2007;  42(6) 442-448
  CrossrefPubMedGoogle Scholar
• 21 Watanabe A, Wada Y, Obata T et al.. Delayed gadolinium-enhanced MR to determine glycosaminoglycan concentration in reparative cartilage after autologous chondrocyte implantation: preliminary results.  Radiology. 2006;  239(1) 201-208
  CrossrefPubMedGoogle Scholar
• 22 Zuo J, Li X, Banerjee S, Han E, Majumdar S. Parallel imaging of knee cartilage at 3 Tesla.  J Magn Reson Imaging. 2007;  26(4) 1001-1009
  CrossrefPubMedGoogle Scholar
• 23 Ramnath R R. 3T MR imaging of the musculoskeletal system (Part I): considerations, coils, and challenges.  Magn Reson Imaging Clin N Am. 2006;  14(1) 27-40
  CrossrefPubMedGoogle Scholar
• 24 Buckwalter J A, Mankin H J. Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation.  Instr Course Lect. 1998;  47 487-504
  PubMedGoogle Scholar
• 25 Poole A R, Kojima T, Yasuda T et al.. Composition and structure of articular cartilage: a template for tissue repair.  Clin Orthop Relat Res. 2001;  (391, Suppl) S26-S33
  CrossrefPubMedGoogle Scholar
• 26 Goodwin D W, Zhu H, Dunn J F. In vitro MR imaging of hyaline cartilage: correlation with scanning electron microscopy.  AJR Am J Roentgenol. 2000;  174(2) 405-409
  PubMedGoogle Scholar
• 27 Clar C, Cummins E, McIntyre L et al.. Clinical and cost-effectiveness of autologous chondrocyte implantation for cartilage defects in knee joints: systematic review and economic evaluation.  Health Technol Assess. 2005;  9(47) iii-iv ix-x 1-82
  PubMedGoogle Scholar
• 28 Smith G D, Knutsen G, Richardson J B. A clinical review of cartilage repair techniques.  J Bone Joint Surg Br. 2005;  87(4) 445-449
  CrossrefPubMedGoogle Scholar
• 29 Steadman J R, Rodkey W G, Rodrigo J J. Microfracture: surgical technique and rehabilitation to treat chondral defects.  Clin Orthop Relat Res. 2001;  (391, Suppl) S362-S369
  CrossrefPubMedGoogle Scholar
• 30 Mithoefer K, Williams III R J, Warren R F et al.. The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study.  J Bone Joint Surg Am. 2005;  87(9) 1911-1920
  CrossrefPubMedGoogle Scholar
• 31 Ueblacker P, Burkart A, Imhoff A B. Retrograde cartilage transplantation on the proximal and distal tibia.  Arthroscopy. 2004;  20(1) 73-78
  PubMedGoogle Scholar
• 32 Hangody L, Rathonyi G K, Duska Z et al.. Autologous osteochondral mosaicplasty. Surgical technique.  J Bone Joint Surg Am. 2004;  86-A(Suppl 1) 65-72
  PubMedGoogle Scholar
• 33 Brittberg M, Lindahl A, Nilsson A et al.. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation.  N Engl J Med. 1994;  331(14) 889-895
  CrossrefPubMedGoogle Scholar
• 34 Minas T, Chiu R. Autologous chondrocyte implantation.  Am J Knee Surg. 2000;  13(1) 41-50
  PubMedGoogle Scholar
• 35 Marlovits S, Zeller P, Singer P, Resinger C, Vecsei V. Cartilage repair: generations of autologous chondrocyte transplantation.  Eur J Radiol. 2006;  57(1) 24-31
  CrossrefPubMedGoogle Scholar
• 36 Bentley G, Biant L C, Carrington R W et al.. A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee.  J Bone Joint Surg Br. 2003;  85(2) 223-230
  CrossrefPubMedGoogle Scholar
• 37 Horas U, Pelinkovic D, Herr G, Aigner T, Schnettler R. Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial.  J Bone Joint Surg Am. 2003;  85-A(2) 185-192
  PubMedGoogle Scholar
• 38 Henderson I J, Tuy B, Connell D, Oakes B, Hettwer W H. Prospective clinical study of autologous chondrocyte implantation and correlation with MRI at three and 12 months.  J Bone Joint Surg Br. 2003;  85(7) 1060-1066
  CrossrefPubMedGoogle Scholar
• 39 Peterson L, Brittberg M, Kiviranta I, Akerlund E L, Lindahl A. Autologous chondrocyte transplantation. Biomechanics and long-term durability.  Am J Sports Med. 2002;  30(1) 2-12
  PubMedGoogle Scholar
• 40 Zheng M H, Willers C, Kirilak L et al.. Matrix-induced autologous chondrocyte implantation (MACI): biological and histological assessment.  Tissue Eng. 2007;  13(4) 737-746
  CrossrefPubMedGoogle Scholar
• 41 Recht M, Bobic V, Burstein D et al.. Magnetic resonance imaging of articular cartilage.  Clin Orthop Relat Res. 2001;  (391, Suppl) S379-S396
  CrossrefPubMedGoogle Scholar
• 42 Disler D G, McCauley T R, Kelman C G et al.. Fat-suppressed three-dimensional spoiled gradient-echo MR imaging of hyaline cartilage defects in the knee: comparison with standard MR imaging and arthroscopy.  AJR Am J Roentgenol. 1996;  167(1) 127-132
  CrossrefPubMedGoogle Scholar
• 43 Peterfy C G, van Dijke C F, Lu Y et al.. Quantification of the volume of articular cartilage in the metacarpophalangeal joints of the hand: accuracy and precision of three-dimensional MR imaging.  AJR Am J Roentgenol. 1995;  165(2) 371-375
  PubMedGoogle Scholar
• 44 Potter H G, Linklater J M, Allen A A, Hannafin J A, Haas S B. Magnetic resonance imaging of articular cartilage in the knee. An evaluation with use of fast-spin-echo imaging.  J Bone Joint Surg Am. 1998;  80(9) 1276-1284
  CrossrefPubMedGoogle Scholar
• 45 Trattnig S, Huber M, Breitenseher M J et al.. Imaging articular cartilage defects with 3D fat-suppressed echo planar imaging: comparison with conventional 3D fat-suppressed gradient echo sequence and correlation with histology.  J Comput Assist Tomogr. 1998;  22(1) 8-14
  PubMedGoogle Scholar
• 46 Kramer J, Recht M P, Imhof H, Stiglbauer R, Engel A. Postcontrast MR arthrography in assessment of cartilage lesions.  J Comput Assist Tomogr. 1994;  18(2) 218-224
  CrossrefPubMedGoogle Scholar
• 47 Marlovits S, Singer P, Zeller P et al.. Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years.  Eur J Radiol. 2006;  57(1) 16-23
  CrossrefPubMedGoogle Scholar
• 48 Marlovits S, Striessnig G, Resinger C T et al.. Definition of pertinent parameters for the evaluation of articular cartilage repair tissue with high-resolution magnetic resonance imaging.  Eur J Radiol. 2004;  52(3) 310-319
  CrossrefPubMedGoogle Scholar
• 49 Recht M P, Piraino D W, Paletta G A, Schils J P, Belhobek G H. Accuracy of fat-suppressed three-dimensional spoiled gradient-echo FLASH MR imaging in the detection of patellofemoral articular cartilage abnormalities.  Radiology. 1996;  198(1) 209-212
  PubMedGoogle Scholar
• 50 Eckstein F, Sittek H, Milz S et al.. The potential of magnetic resonance imaging (MRI) for quantifying articular cartilage thickness—a methodological study.  Clin Biomech (Bristol, Avon). 1995;  10(8) 434-440
  CrossrefPubMedGoogle Scholar
• 51 Eckstein F, Winzheimer M, Westhoff J et al.. Quantitative relationships of normal cartilage volumes of the human knee joint—assessment by magnetic resonance imaging.  Anat Embryol (Berl). 1998;  197(5) 383-390
  CrossrefPubMedGoogle Scholar
• 52 Gray M L, Eckstein F, Peterfy C et al.. Toward imaging biomarkers for osteoarthritis.  Clin Orthop Relat Res. 2004;  (427, Suppl) S175-S181
  CrossrefPubMedGoogle Scholar
• 53 Eckstein F, Kunz M, Schutzer M et al.. Two year longitudinal change and test-retest-precision of knee cartilage morphology in a pilot study for the osteoarthritis initiative.  Osteoarthritis Cartilage. 2007;  15(11) 1326-1332
  CrossrefPubMedGoogle Scholar
• 54 Eckstein F, Hudelmaier M, Wirth W et al.. Double echo steady state magnetic resonance imaging of knee articular cartilage at 3 Tesla: a pilot study for the Osteoarthritis Initiative.  Ann Rheum Dis. 2006;  65(4) 433-441
  CrossrefPubMedGoogle Scholar
• 55 Weckbach S, Mendlik T, Horger W et al.. Quantitative assessment of patellar cartilage volume and thickness at 3.0 Tesla comparing a 3D-fast low angle shot versus a 3D-true fast imaging with steady-state precession sequence for reproducibility.  Invest Radiol. 2006;  41(2) 189-197
  CrossrefPubMedGoogle Scholar
• 56 Kornaat P R, Reeder S B, Koo S et al.. MR imaging of articular cartilage at 1.5T and 3.0T: comparison of SPGR and SSFP sequences.  Osteoarthritis Cartilage. 2005;  13(4) 338-344
  CrossrefPubMedGoogle Scholar
• 57 Duc S R, Koch P, Schmid M R et al.. Diagnosis of articular cartilage abnormalities of the knee: prospective clinical evaluation of a 3D water-excitation true FISP sequence.  Radiology. 2007;  243(2) 475-482
  CrossrefPubMedGoogle Scholar
• 58 Duc S R, Pfirrmann C W, Koch P P, Zanetti M, Hodler J. Internal knee derangement assessed with 3-minute three-dimensional isovoxel true FISP MR sequence: preliminary study.  Radiology. 2008;  246(2) 526-535
  CrossrefPubMedGoogle Scholar
• 59 Duc S R, Pfirrmann C W, Schmid M R et al.. Articular cartilage defects detected with 3D water-excitation true FISP: prospective comparison with sequences commonly used for knee imaging.  Radiology. 2007;  245(1) 216-223
  CrossrefPubMedGoogle Scholar
• 60 Gold G E, Busse R F, Beehler C et al.. Isotropic MRI of the knee with 3D fast spin-echo extended echo-train acquisition (XETA): initial experience.  AJR Am J Roentgenol. 2007;  188(5) 1287-1293
  CrossrefPubMedGoogle Scholar
• 61 Burstein D, Bashir A, Gray M L. MRI techniques in early stages of cartilage disease.  Invest Radiol. 2000;  35(10) 622-638
  CrossrefPubMedGoogle Scholar
• 62 Bashir A, Gray M L, Boutin R D, Burstein D. Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging.  Radiology. 1997;  205(2) 551-558
  CrossrefPubMedGoogle Scholar
• 63 Tiderius C J, Olsson L E, Leander P, Ekberg O, Dahlberg L. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis.  Magn Reson Med. 2003;  49(3) 488-492
  CrossrefPubMedGoogle Scholar
• 64 Williams A, Gillis A, McKenzie C et al.. Glycosaminoglycan distribution in cartilage as determined by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): potential clinical applications.  AJR Am J Roentgenol. 2004;  182(1) 167-172
  PubMedGoogle Scholar
• 65 Trattnig S, Marlovits S, Gebetsroither S et al.. Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) for in vivo evaluation of reparative cartilage after matrix-associated autologous chondrocyte transplantation at 3.0T: preliminary results.  J Magn Reson Imaging. 2007;  26(4) 974-982
  CrossrefPubMedGoogle Scholar
• 66 Kim Y J, Jaramillo D, Millis M B, Gray M L, Burstein D. Assessment of early osteoarthritis in hip dysplasia with delayed gadolinium-enhanced magnetic resonance imaging of cartilage.  J Bone Joint Surg Am. 2003;  85-A(10) 1987-1992
  PubMedGoogle Scholar
• 67 Vaga S, Raimondi M T, Caiani E G et al.. Quantitative assessment of intervertebral disc glycosaminoglycan distribution by gadolinium-enhanced MRI in orthopedic patients.  Magn Reson Med. 2008;  59(1) 85-95
  CrossrefPubMedGoogle Scholar
• 68 Williams A, Shetty S K, Burstein D, Day C S, McKenzie C. Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) of the first carpometacarpal (1CMC) joint: a feasibility study.  Osteoarthritis Cartilage. 2008;  16(4) 530-532
  CrossrefPubMedGoogle Scholar
• 69 Ling W, Regatte R R, Navon G, Jerschow A. Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST).  Proc Natl Acad Sci USA. 2008;  105(7) 2266-2270
  CrossrefPubMedGoogle Scholar
• 70 Mosher T J, Dardzinski B J. Cartilage MRI T2 relaxation time mapping: overview and applications.  Semin Musculoskelet Radiol. 2004;  8(4) 355-368
  Article in Thieme ConnectPubMedGoogle Scholar
• 71 Goodwin D W, Wadghiri Y Z, Dunn J F. Micro-imaging of articular cartilage: T2, proton density, and the magic angle effect.  Acad Radiol. 1998;  5(11) 790-798
  CrossrefPubMedGoogle Scholar
• 72 Smith H E, Mosher T J, Dardzinski B J et al.. Spatial variation in cartilage T2 of the knee.  J Magn Reson Imaging. 2001;  14(1) 50-55
  CrossrefPubMedGoogle Scholar
• 73 Watrin-Pinzano A, Ruaud J P, Cheli Y et al.. Evaluation of cartilage repair tissue after biomaterial implantation in rat patella by using T2 mapping.  MAGMA. 2004;  17(3–6) 219-228
  CrossrefPubMedGoogle Scholar
• 74 White L M, Sussman M S, Hurtig M et al.. Cartilage T2 assessment: differentiation of normal hyaline cartilage and reparative tissue after arthroscopic cartilage repair in equine subjects.  Radiology. 2006;  241(2) 407-414
  CrossrefPubMedGoogle Scholar
• 75 Welsch G H, Mamisch T C, Domayer S E et al.. Cartilage T2 assessment at 3-T MR imaging: in vivo differentiation of normal hyaline cartilage from reparative tissue after two cartilage repair procedures—initial experience.  Radiology. 2008;  247(1) 154-161
  CrossrefPubMedGoogle Scholar
• 76 David-Vaudey E, Ghosh S, Ries M, Majumdar S. T2 relaxation time measurements in osteoarthritis.  Magn Reson Imaging. 2004;  22(5) 673-682
  CrossrefPubMedGoogle Scholar
• 77 Dunn T C, Lu Y, Jin H, Ries M D, Majumdar S. T2 relaxation time of cartilage at MR imaging: comparison with severity of knee osteoarthritis.  Radiology. 2004;  232(2) 592-598
  CrossrefPubMedGoogle Scholar
• 78 Burstein D, Gray M L. Is MRI fulfilling its promise for molecular imaging of cartilage in arthritis?.  Osteoarthritis Cartilage. 2006;  14(11) 1087-1090
  CrossrefPubMedGoogle Scholar
• 79 Murphy B J. Evaluation of grades 3 and 4 chondromalacia of the knee using T2*-weighted 3D gradient-echo articular cartilage imaging.  Skeletal Radiol. 2001;  30(6) 305-311
  CrossrefPubMedGoogle Scholar
• 80 Hughes T, Welsch G H, Trattnig S et al.. T2-star relaxation as a means to differentiate cartilage repair tissue after microfracturing therapy.  Intern Soc Magn Reson Med. 2007;  15 183
  PubMedGoogle Scholar
• 81 Wietek B, Martirosian P, Machann J et al.. T2 and T2* mapping of the human femoral-tibial cartilage at 1.5 and 3 Tesla.  Intern Soc Magn Reson Med. 2007;  15 516
  PubMedGoogle Scholar
• 82 Bauer J S, Banerjee S, Henning T D et al.. Fast high-spatial-resolution MRI of the ankle with parallel imaging using GRAPPA at 3 T.  AJR Am J Roentgenol. 2007;  189(1) 240-245
  CrossrefPubMedGoogle Scholar
• 83 Mosher T J. Musculoskeletal imaging at 3T: current techniques and future applications.  Magn Reson Imaging Clin N Am. 2006;  14(1) 63-76
  CrossrefPubMedGoogle Scholar
• 84 Rayan F, Bhonsle S, Shukla D D. Clinical, MRI, and arthroscopic correlation in meniscal and anterior cruciate ligament injuries.  Int Orthop. 2008;  , E-pub ahead of print
  PubMedGoogle Scholar
• 85 Thomas S, Pullagura M, Robinson E, Cohen A, Banaszkiewicz P. The value of magnetic resonance imaging in our current management of ACL and meniscal injuries.  Knee Surg Sports Traumatol Arthrosc. 2007;  15(5) 533-536
  CrossrefPubMedGoogle Scholar
• 86 Gold G E, Han E, Stainsby J et al.. Musculoskeletal MRI at 3.0 T: relaxation times and image contrast.  AJR Am J Roentgenol. 2004;  183(2) 343-351
  CrossrefPubMedGoogle Scholar
• 87 Pakin S K, Cavalcanti C, La Rocca R, Schweitzer M E, Regatte R R. Ultra-high-field MRI of knee joint at 7.0T: preliminary experience.  Acad Radiol. 2006;  13(9) 1135-1142
  CrossrefPubMedGoogle Scholar
• 88 Stanisz G J, Odrobina E E, Pun J et al.. T1, T2 relaxation and magnetization transfer in tissue at 3T.  Magn Reson Med. 2005;  54(3) 507-512
  CrossrefPubMedGoogle Scholar
• 89 Williams A, Mikulis B, Krishnan N et al.. Suitability of T(1Gd) as the dGEMRIC index at 1.5T and 3.0T.  Magn Reson Med. 2007;  58(4) 830-834
  CrossrefPubMedGoogle Scholar
• 90 Dietrich O, Raya J G, Reeder S B, Reiser M F, Schoenberg S O. Measurement of signal-to-noise ratios in MR Images: influence of multichannel coils, parallel imaging, and reconstruction filters.  J Magn Reson Imaging. 2007;  26 375-385
  CrossrefPubMedGoogle Scholar
• 91 Liess C, Lusse S, Karger N, Heller M, Gluer C C. Detection of changes in cartilage water content using MRI T2-mapping in vivo.  Osteoarthritis Cartilage. 2002;  10(12) 907-913
  CrossrefPubMedGoogle Scholar
• 92 Domayer S E, Kutscha-Lissberg F, Welsch G et al.. T2 mapping in the knee after microfracture at 3.0T: correlation of global T2 values and clinical outcome—preliminary results.  Osteoarthritis Cartilage. 2008;  , E-pub ahead of publication
  PubMedGoogle Scholar

Goetz H WelschM.D. 

MR Center–High Field MR, Department of Radiology, Medical University of Vienna

Lazarettgasse 14, A-1090 Vienna, Austria

Email: welsch@bwh.harvard.edu