Regular ArticleVasopressin and oxytocin receptor mRNA expression during rat telencephalon development
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2018, Neuroscience and Biobehavioral ReviewsCitation Excerpt :These behavioural changes are accompanied by pronounced and prolonged structural modifications in several brain regions implicated in social cognition, namely parts of prefrontal, parietal and superior temporal cortices (Blakemore, 2008). Although already present in the prenatal developing brain, preclinical evidence suggests that the expression of the receptors of AVP (arginine vasopressin receptor 1 A [V1aR]) and OT (oxytocin receptor [OTR]) change quantitatively and topologically during pre- and post-natal development (Altstein and Gainer, 1988; Chen et al., 2000; Hammock, 2015; Grinevich et al., 2014). Their distribution patterns in the brain depend on age and species, with quantitative levels being modulated by gonadal hormones and experience.
Prenatal bisphenol A (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study
2018, NeuroToxicologyCitation Excerpt :In adult rodents, Oxtr and Avpr1a, are robustly expressed throughout the brain and have been found in several amygdalar subnuclei, including the central nucleus and medial amygdala (Dumais and Veenema, 2016). Their receptors are also present during development and both can be detected in the fetal rat brain as early as embryonic day 12 (Chen et al., 2000). Numerous studies in rodents and non-human primates clearly demonstrate that changes in the OXT or AVP system during early life can permanently alter the brain and behavior (Bales and Perkeybile, 2012; Hammock, 2015; Miller and Caldwell, 2015; Veenema, 2012).
Oxytocin, Vasopressin, and Development of Social Behavior in Primates
2016, Evolution of Nervous Systems: Second EditionSchizophrenia and alcohol dependence: Diverse clinical effects of oxytocin and their evolutionary origins
2014, Brain ResearchCitation Excerpt :The adult pattern of OT binding did not emerge until puberty. OT receptor mRNA has been found in the rat telencephalon as early as fetal day 12 although it is unclear if the receptor is expressed that early (Chen et al., 2000). Analogous with the results of autoradiography studies in postnatal rat brains, we have preliminary, unpublished evidence that OT receptor immunostaining in second trimester human fetal brain is located in sites, such as the hippocampus, where immunostaining was not found by Boccia et al. (2013) in the adult human brain.
Heightened aggressive behavior in mice with lifelong versus postweaning knockout of the oxytocin receptor
2012, Hormones and BehaviorCitation Excerpt :Though, based on studies in rats, there is the potential for Oxt to signal via the Oxtr during embryonic development. Beginning as early as embryonic days 12–14 there is evidence of stable Oxtr expression, and during postnatal development quite a bit of transient Oxtr expression (Chen et al., 2000; Tribollet et al., 1989; Yoshimura et al., 1996). In the embryonic rat brain, Oxtr can be found in the anterior olfactory nucleus, tenia tecta, some amygdaloid nuclei, piriform cortex, ventromedial hypothalamic nucleus, subiculum, prepositus hypoglossal nucleus, and the dorsal motor nucleus of vagus (Yoshimura et al., 1996).
Developmental experiences and the oxytocin receptor system
2012, Hormones and BehaviorCitation Excerpt :OTR in the rat brain are present during development, as detected by gene expression (Chen et al., 2000; Yoshimura et al., 1996) and receptor binding autoradiography (Tribollet et al., 1989), during embryonic life beginning at E12–14. AVP V1a and V2 are also detectable in rat telencephalon from E12 (Chen et al., 2000). In rats, two populations of OTR gene expression can be differentiated, one group that is expressed transiently [including the caudate putamen (CP), cingulate cortex (CC), anterior thalamic nuclei, and ventral tegmental area] and a group that has constant, abundant expression [including the anterior olfactory nucleus, tenia tecta, BNST, ventromedial hypothalamic nucleus (VMH)] (Yoshimura et al., 1996).