Race- and sex-specific ECG models for left ventricular mass in older populations. factors influencing overestimation of left ventricular hypertrophy prevalence by ECG criteria in African-Americans☆,☆☆,★,★★,♢,♢♢,♦
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2017, Clinical Trials and Regulatory Science in CardiologyCitation Excerpt :Sokolow Lyon criteria have mainly been developed on white populations and reasons why these criteria are more likely to result into false positive LVH diagnosis in African origin populations have been attributed to socioeconomic and nutritional factors, differences in body shape, fat distributions, and physiological differences in ventricle sizes [30,31]. Higher QRS amplitudes in older populations of African-Americans as compared to white populations have been described for both men and women despite comparable left ventricular mass as measured by echocardiography, indicating racial differences which were partly explained by smaller lateral chest diameter in individuals of African origin [32]. As reviewed by Fraley et al. [33], higher BMI or obesity is known to lead to lower QRS voltages effecting especially ECG LVH criteria that rely on left or right precordial voltage such as the Sokolow Lyon Index.
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†Division of Cardiology, Georgetown University Medical Center, Washington, DC,
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‡the CHS Coordinating Center, University of Washington, Seattle, WA,
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§the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD,
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∥Division of Cardiology, Albany Medical College, Albany, NY,
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¶The John Hopkins University, Baltimore, MD.
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Supported by contracts N01-HC-85079 through N01-HC-8586 from the National Heart, Lung, and Blood Institute, and Georgetown Echo RC-HL 35129. A list of the participating institutions and principal staff is in the Appendix.
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Reprint requests: Pentti M. Rautaharju, MD, PhD, EPICARE Center, Suite 505, Piedmont Plaza Two, 2000 West First Street, Winston-Salem, NC 27104.