Abstract
We investigated three patients with cardiac angiosarcomas and two with cardiac rhabdomyosarcomas, all for mutations at exons 5, 6, 7 and 8 of the p53 gene and at exon 1 of K- ras. No point mutations were observed in the p53 gene in any of the five cases; however, at exon 1 of K- ras, three patients (60%) presented the same mutation at the first base of codon 13 (G to A transition). Interestingly, this mutation was detected in both rhabdomyosarcoma and angiosarcoma histologic sarcoma types. © 2000 Cancer Research Campaign
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Garcia, J., Gonzalez, R., Silva, J. et al. Mutational status of K- ras and TP53 genes in primary sarcomas of the heart. Br J Cancer 82, 1183–1185 (2000). https://doi.org/10.1054/bjoc.1999.1060
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DOI: https://doi.org/10.1054/bjoc.1999.1060
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