Prostaglandins, Leukotrienes and Essential Fatty Acids
Regular ArticleDepression and adipose essential polyunsaturated fatty acids
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Temporal associations of BMI and glucose parameters with depressive symptoms among US adults
2024, Psychiatry Research<inf>Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications</inf>
2023, Progress in Lipid ResearchHow lipids may affect risk for suicidal behavior
2018, Journal of Psychiatric ResearchCitation Excerpt :Higher blood levels of n-6 PUFAs also have been reported in association with higher suicide risk and depression in a study of 234 pregnant women (Vaz et al., 2014). Lower n-3 PUFA levels are also observed in depressed patients compared with healthy controls, in plasma (Dinan et al., 2009; Féart et al., 2008; Frasure-Smith et al., 2004; Rees et al., 2009; Tiemeier et al., 2003) and serum phospholipids (Conklin et al., 2007; Maes et al., 1999; Riemer et al., 2010; Schins et al., 2007), red blood cell membranes (Adams et al., 1996; Amin et al., 2008; Edwards et al., 1998; McNamara et al., 2010b; Peet et al., 1998), and adipose tissue (Mamalakis, 2002; Mamalakis et al., 2006a, 2006b; Papandreou et al., 2011; Sarri et al., 2008), and confirmed by meta-analytic findings (Lin et al., 2010). These relationships are relevant since depression is one of the main risk factors associated with suicidal behavior (Teti et al., 2014).
A controlled study of plasma fatty acids in Indian patients with depressive episode
2018, Asian Journal of PsychiatryCitation Excerpt :These findings suggest an abnormal intake or metabolism of essential fatty acids in conjunction with decreased formation of cholesteryl esters in major depression. The depressed subjects had significantly lower adipose tissue DHA levels than the non-depressed subjects (Mamalakis et al., 2002). Meta-analytic studies show the levels of EPA, DHA, and total omega-3 polyunsaturated fatty acids (PUFA) were significantly low in depressive patients and omega-3 PUFAs have a significant antidepressant effect (Lin et al., 2010; Lin and Su, 2007).
A MIR4646 associated methylation locus is hypomethylated in adolescent depression
2017, Journal of Affective Disorders
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Correspondence to: G. Mamalakis MA, Department of Social and Preventive Medicine, School of Medicine, University of Crete, P. O. Box 1393 Iraklion, Crete, Greece. E-mail: [email protected]